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《The Journal of Bone and Joint Injury》 2001-06
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An Experimental Research of Refrigeration with Liquid Nitrogen to ONFH

Wang Weiming,Zhao Dewei,Depatrment of Orthopaedics, 4 th Hospital,Dalian Medical University,Dalin,116001  
Objective To study the effect on osteonecrosis of femoral head (ONFH) after being frozen instantly by liquid nitrogen which can provide an experimental basis for an animal model of osteonecrosis of the femoral head.Methods Sixty adult rabbits were divided into three groups. They were suffered an instantly refrigeration with liquid nitrogen at the femoral head. All animals were observed about their radiographic, gross and microscopy manifestation of the femoral head.Results There were significant changes in gross and microscopy manifestation of the femoral head which being frozen instantly by liquid nitrogen.Conclusion Freezing the femoral head with liquid nitrogen provided an simple and convenient technique for making an animal model of osteonecrosis of the femoral head.
【CateGory Index】: R-332;R681.8
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