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《The Journal of Bone and Joint Injury》 2005-10
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Study on Bioactivity of the Nano-hydroapatite Crystals and Polyamide Composite(n-HA/PA66) and Its Effects to Bodys Metabolism of Calcium and Phosphorus

Meng Chunyang,An Hong,Jiang Dianming.Department of Orthopaedics,the First Affiliated Hospital of Chongqing University of Medical Sciences,Chongqing,400016,China  
Objective To investigate the bioactivity of nano-hydroapatite crystals and polyamide composite(n-HA/PA66),and the effects it would be to bodys metabolism of calcium and phosphorus.Methods The n-HA/PA66 composite were implanted in rabbits muscle and bone tissue,the value of Ca 2+ and P 3+ were detected postoperation 4 d,1 week and 2 week,this group set up sham operation group as blank control;The specimens were harvested postoperation 1,2,3,4,and 8 weeks respectively and examined by SEM and histology to evaluate the surface and interface of composite and receiptor bone.Results The results showed that on the composite surface had much new crystals of apatite fomation;At the interface between receiptor bone and composite had new bone regeneration,it had no evident effects to bodys metabolism of calcium and phosphorus(P0.05).Conclusion The n-HA/PA66 composite have good bioactivity and no effects to bodys metabolism of calcium and phosphorus.
【Fund】: 国家“863”计划资助项目(编号:2002AA326020)
【CateGory Index】: R318.08
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