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《Chinese Journal of Bone and Joint Injury》 2009-05
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Multiple Systems for Evaluatation of Models of Osteonecrosis of Femoral Head by Liquid Nitrogen Frozen Plus Passive Forced Motion

Tong Peijian,Shen Yan,He Bangjian,et al.The First Hospital A ffiliated to Zhejiang University of TCM,Hangzhou,310006  
Objective To evaluate an animal model of osteonecrosis of femoral head.Methods Eight Beagle dogs were selected,and the model of osteonecrosis of femoral head was established by liquid nitrogen frozen plus passive forced motion.Meanwhile,the left side served as control groups.Histological slices of femoral head were harvested on postoperative weeks 1、4、8 and 16 for HE staining.The osteonecrosis of femoral head was observed by magnetic resonance imaging at 1、8 and 16 weeks after operation.DSA was performed before operation and sacrificing the animals to compare the pre-and post-operation blood supply surrounding femoral head.Results Pathological sections suggested that all operated femoral heads showed osteonecrosis at different levels,moreover,slightly collapse was appeared in the 16-week specimen;MRI showed the scattered low signals were found in the operated femoral heads at the 8 week on T2WI,which were enlarged at the 16 week;DSA images displayed that stenosis or blockage at different levels of blood vessels which supply the femoral head,mean-while,a plenty of new blood vessels grew into the femoral head through the neck of femur,and bone marrow,but most of them could not reach the necrotic area.Conclusion Liquid nitrogen frozen plus passive forced motion is an ideal method to establish the animal model of osteonecrosis of femoral head that consists with the pathological change of osteonecrosis of the femoral head.
【Fund】: 浙江省中医药管理局重点资助项目(2005Z003)
【CateGory Index】: R681.8;R-332
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【References】
Chinese Journal Full-text Database 1 Hits
1 XIE Zhi-tao;ZHAO De-wei;JIANG Lei;Department of Orthopaedics, Affiliated Zhongshan Hospital of Dalian University;;Experimental study of avascular necrosis of femoral head of dogs induced by methylprednisolone and endotoxin[J];Chinese Journal of Bone and Joint Injury;2014-06
【Citations】
Chinese Journal Full-text Database 4 Hits
1 Wang Weiming,Zhao Dewei,Depatrment of Orthopaedics, 4 th Hospital,Dalian Medical University,Dalin,116001;An Experimental Research of Refrigeration with Liquid Nitrogen to ONFH[J];The Journal of Bone and Joint Injury;2001-06
2 Mei Rongcheng,Yang Shuhua,Yang Cao,et al.Department of Orthopedics,Union Hospital of Tongji Medical College of Huazhong Science and Technology University,Wuhan,430022;Treatment of Osteonecrosis of Femoral Head with Implantation of Allogeneic Bone Support Frame,Autologous Bone and Decalcified Bone Matrix[J];Chinese Journal of Bone and Joint Injury;2007-01
3 Liu Zhaohui,Guo Wanshou,Zhang Nianfei,et al.Department Orthopedics,China-Japan Friendship Hospital,Beijing,100029;Diagnosis of Osteonecrosis of Femoral Head with Atypical Imaging[J];Chinese Journal of Bone and Joint Injury;2008-05
4 ZHOU Qiang,LI Qihong,YANG Liu,et al.Department of Orthopaedics,Southwest Hospital,Third Military Medical University,Chongqing 400038, China.;Changes of blood vessels in glucocorticoid induced avascular necrosis of femoral head in rabbits[J];Chiese Journal of Surgery;2000-03
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 JIA Yong,CHU Tong-wei,ZHOU Yue(1.Department of Orthopaedics,Wulumuqi General Hospital of Lanzhou Military Area,Wulunmuqi 830000,China;2.Department of Orthopaedics,Xinqiao Hospital,Third Military Medical University,Chongqing 400037,China);Repair process in experimentally induced avascular necrosis of femoral head in rabbits[J];Chongqing Medicine;2006-02
2 ZHOU Qiang, SHI Guo-hua, YANG Liu, TAN Zu-jian, DAI Gang, TANG Kang-lai (Department of Orthopedics, Southwest Hospital, Third Military Medical University, Chongqing 400038, China);Histological observation on effects of degradable porous polymer with osteo-inducing factors in healing of femur head necrosis[J];Acta Academiae Medicine Militaris Tertiae;2002-05
3 KONG Ling-Bo,NIU Shun,YANG Chong-Fei,ZHU Qing-Sheng Institute of Orthopaedics,Fourth Military Medical University,Xi'an 710033,China;Establishment and evaluation of rabbit model of femoral head avascular necrosis[J];Journal of the Fourth Military Medical University;2009-02
4 LIU Guo-zhu, YANG Tong-tao, HAN Jian-wei, WU Jin, WEN Yan-hua, GAO Jie, MA Bao-an Department of Orthopedics, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, China;An improved liquid nitrogen freezing method for establishing canine models of femoral head necrosis[J];Journal of Southern Medical University;2009-08
5 GAO Ke-jia*,LI Ming-qi,MAO Cheng-zhong,YE Zhi-wei,WANG Jian-hua,MEI Xiao-gang,ZHAO Lin-mei.*Department of Nucleur Medicine,Shanghai Huangpu District Central Hospital,Shanghai 200002 China;The animal experiment and preliminary study of femur head necrosis treated by ~(99)T_(c-)MDP[J];Chinese Journal of Rheumatology;2004-02
6 DONG Yue,WEN Feng,WU Zhen-hua,et al.Department of Radiology,the First Affiliated Hospital of Dalian Medical University,Liaolin 116011,P.R.China;Experimental Investigation of Multi-slice CT Perfusion and Vascular Endothelium Growth Factor Expression in Steroid Induced Femoral Head Necrosis[J];Radiologic Practice;2006-05
7 Chen Guangxiang,Dong Tianhua,Huang Shizhong.Department of Orthopaedics,The Second Peoples Hospital of Suzhou,Suzhou,215002;Experimental Study about the Osteogenic Activity of the Muscle Pedicle Bone Graft[J];The Journal of Bone and Joint Injury;2001-03
8 Tang Hongtao,Tong Yunhui,Yang Ruping,et al.Luoyan Orthopadic Hospital,Luoyan,471002;Biomechanics Significance of Femoral Head and Neck of Grafting-bone Group After Femoral Neck Fracture-healing[J];Chinese Journal of Bone and Joint Injury;2011-04
9 CUI Xilong,LI Zhanghua,DAI Shuangwu,LI Dan,DU Li,XI Meili,YUE Chaohong,CHEN Youhao Dept.of Orthopaedics,Renmin Hospital of Wuhan University,Wuhan 430060,China;Establishment of a Modified Model of Non-Traumatic Avascular Necrosis of Femoral Head in Rabbits[J];Medical Journal of Wuhan University;2010-01
10 LI Peiyong; ZHANG Huan; ZHANG JixianZHU Chengmo; SUN Zhengming; YANG Qingming(Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025);The early assessment of avascular necrosis of femur head in dogs by dynamic bone imaging[J];NUCLEAR TECHNIQUES;1998-05
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 BAI Liang chuan,XU Guan sun,ZHANG Rong jun,LIU Gang (The Second department of Clinic Medicine,Anhui College of Traditional Chinese Medicine,Anhui Hefei 230038,China);Effect of Electroacupuncture on Regional Tissue Blood Flow in Rabbits with Steroid-induced Avascular Necrosis of Femoral Head[J];Journal of Anhui Traditional Chinese Medical College;2004-01
2 Wang Haibin Zhao Younfang Shi Yinyu et al △Postdoctoral Workstation of Department of Orthopedics,First Affiliated Hospital of Guangzhou University of TCM & Pharmacology,Guangzhou (510405).;Effect Vascular of in Early Steroid Induced Ischemic Necrosid of Femoral Head by Chinese Mecicine[J];Journal of Zhejiang College of Tcm;2000-06
3 ZHOU Qiang, LI Qi hong, YANG Liu, LIU Feng xian, CAO Jia (Department of Orthopedics, Southwest Hospital, Third Military Medical University, Chongqing 400038,China);Study of femoral head necrosis induced with large dosages of glucocorticoid in rabbits[J];ACTA ACADEMIAE MEDICINE MILITARIS TERTIAE;2000-03
4 CAO Lan-Xiu,ZHOU Yong-Xue,DUN Bao-Sheng,ZHAO XianDepartment of Traditional Medical Formulae,Shaanxi University of Traditional Chinese Medicine,Xianyang 712046,China;Lipometabolism effect of total flavonoid in ligustrum lucidum ait on hyperlipidemic model[J];Journal of the Fourth Military Medical University;2009-20
5 HU Zhi-ming, ZHOU Ming-qian, GAO Ji-min College of Biotechnology, Southern Medical University, Guangzhou 510515,China;Effect of vascular endothelial growth factor and tumor necrosis factor receptor for treatment of avascular necrosis of the femoral head in rabbits[J];Journal of Southern Medical University;2008-12
6 HE Zhen-guo,WANG Hua-song,HUANG Qiong-xia (Departmnet of Bong,TongJi Affiliated Hospital,TongJi Medical University,Wuhan 430030)$$$$;The Experimental Research on Prophylaxis and Treatment of Hormon-induced Osteonecrosis of the Femoral Head with Zhengu Jianbu Tang[J];Journal of Hubei Institute For Nationalities Medical Edition;2001-01
7 QI Zhen-xi~(1),CHEN Lei~(2)(1.Technology Industry Department,FCTCM,Fuzhou,Fujian 350003,China;2.Orthopaedic and Traumatology Department,FCTCM,Fuzhou,Fujian 350108,China);Expression and Its Significance of VEGF in Rabbits of Hormonal Avascular Necrosis of Femoral Head[J];Journal of Fujian College of Traditional Chinese Medicine;2006-05
8 QI Zhen-xi1,KANG Jing-dong2,LI Shu-qiang2(1. Technology Industry Department,FUTCM,Fuzhou,Fujian 350003,China;2. Orthopaedic and Traumatology Department,FUTCM,Fuzhou,Fujian 350108,China);Effect of Taohong Siwu Decoction on Transcription of Transforming Growth Factor-β_1 mRNA of Hormonal Avascular Necrosis of Femoral Head in Rats[J];Journal of Fujian University of Traditional Chinese Medicine;2009-01
9 ZHAO Jindong,LU Songcen,XUE Zhen,et al.Department of Orthopadics,The Second affiliated Hospital of Harbin Medical University,Harbin 045100,China;Establish and evaluate animal models of steriod-induced osteonecrosis of the femoral head[J];Chinese Journal of Bone Tumor and Bone Disease;2007-04
10 CUI Xilong,LI Zhanghua,DAI Shuangwu,LI Dan,DU Li,XI Meili,YUE Chaohong,CHEN Youhao Dept.of Orthopaedics,Renmin Hospital of Wuhan University,Wuhan 430060,China;Establishment of a Modified Model of Non-Traumatic Avascular Necrosis of Femoral Head in Rabbits[J];Medical Journal of Wuhan University;2010-01
【Secondary References】
Chinese Journal Full-text Database 1 Hits
1 DUAN Rui-qi1,LIU Wen-gang2,OU Yu-qiang3(1.The Orthopedics and Traumatology Hospital Affiliated to Guangzhou University of Chinese Medicine,Guangdong Guangzhou 510240,China;2.Guangdong Second Provincial Traditional Chinese Medicine,Guangdong Guangzhou 510095,China;3.Zhaoqing Traditional Chinese Medicine Hospital,Guangdong Zhaoqing 506020,China);Induction of CYP3A in liver Cell of Rabbits and Prevention of Steroid-Induced Osteonecrosis of Femoral Head by "GU KANG"[J];Guiding Journal of Traditional Chinese Medicine and Pharmacy;2013-07
【Secondary Citations】
Chinese Journal Full-text Database 4 Hits
1 Yue Debo,Li Zirong.Peking Union Medical College Post Graduate School of Medicine,Beijing,100029;Magnetic Resonance Imaging Appearance of Spontaneous Osteonecrosis-like Lesions in 68 Patients[J];Chinese Journal of Bone and Joint Injury;2007-08
2 WANG Yan, WANG Jifang, LU Shibi, Department of Orthopaedics, Chinese General Hospital of Peoples Liberation Army, Beijing 100853,China;Flexible cage implantation for treatment of advanced osteonecrosis of femoral head in adolescence[J];CHINESE JOURNAL OF ORTHOPAEDICS;2000-05
3 LIU Ji-hua,GAO Zhen-hua,XU Ai-de,XU Wen-jian,WANG Jing-qun.Department of Radiology,Affiliated Hospital of Medical College of Qingdao University,Qingdao 266003,China;The comparative study of imageology and imageological examining procedure on the early femoral head necrosis in adult[J];Chinese Journal of Radiology;2004-03
4 MEI Rong-cheng,YANG Shu-hua,YANG Cao,et al.Department of Orthopaedics,Union Hospital of Tongji Medical College of Huazhong Science and Technology University,Wuhan 430022;Treatment of osteonecrosis of the femoral head with implantation of titanium alloy support frame,autologous bone and decalcified bone matrix[J];Orthopedic Journal of China;2006-07
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