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《CHINESE JOURNAL OF HISTOCHEMISTRY AND CYTOCHEMISTRY》 2000-01
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CO-EXISTANCE OF 5-HT AND NITRIC OXIDE SYNTHASE IN THE NEURONS OF RAT MIDBRAIN PERIAQUDUCTAL GRAY AND RAPHE NUCLEAR COMPLEX

Tian Meiling, Ling Shucai (Department of Neurobiolgy, Nantong Medical College, Nantong 226001 China)  
By using the method of NADPA d histochemisty combining with serotonin (5 HT) immunocyto chemistry technique, we investigated the distribution of nitric oxide synthase (NOS) and 5 HT, and the coexistence of them in the midbrain periaqueductal gray(PAG) and raphe nuclear complex of the rat. The results showed that numerous neurons in the PAG and raphe nuclear complex displayed both 5 HT like immunoreactivity (5 HT LI) and NOS positivity: (1)Within the midial portion of the PAG ventrolateral subdivision (VLS), a large number of 5 HT LI neurons and NOS positive neurons were observed, whereas about 20 1% of the 5 HT LI neurons displayed NOS positivity within the lateral portion of VLS. Dense NOS positive neurons were observed within dorsolateral subdivision of PAG. However, 5HT LI neurons were rarely seen in this subdivision. (2) In the majority of subnucleus of raphe nuclear complex, a lot of neurons were doubly labeled. Cell counts showed that about 44 6%, 53 4%,44 4%,26 2%,26 7% and 21 8% of 5 HT LI neurons displayed NOS positivity in the midial subdivision of the nucleus raphe dorsalis (DR), the caldal subdivision of DR, nucleus raphe midian, caldal subdivision of nucleus lineris and nucleus raphe magnus and nucleus raphe obcuse, respectively. However, sparse doubly labeled neurons were observed in nucleus raphe pallidus. These results suggest there are some functional correation between 5 HT and NO. The functional role of double labeled neurons remains to be further investigated.
【Fund】: 江苏省自然科学基金资助项目!(No. BK971 5 0 );; 江苏省“333工程”培养基金资助项目!〔No.苏科基(1 998) 0 0 4〕
【CateGory Index】: Q95-3
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