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《CHINESE JOURNAL OF HISTOCHEMISTRY AND CYTOCHEMISTRY》 2000-01
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EXPERIMENTAL STUDIES ON ANTI CANCER FUNCTION OF PIC-BE

Lu Bufeng, Yu Limin, Bian Chunxiang, Shao Shujuan, Zhu Zhengmei, Yang Peiman (Key Laboratory of Cellular and Molecular Biology of Liaoning Province, Dalian Medical University, Dalian 116027,China)  
The characteristics of anti cancer function of PIC BE, a kind of water soluble derivative of β elemente, on K 562 and K 562 /ADM cell lines were studied. The results showed: (1) K 562 /ADM cell line was 40 fold more resistant to ADM than K 562 cell line, but the IC 50 values of both cell lines to PIC BE showed no significant difference ( P 0 05). (2)Qualitative and quantitative assays showed that PIC BE (10 0-30 0μg/ml) could inhibit cell growth and induce apoptosis obviously ( P 0 05 or P 0 01), and the effects were dose and time dependent within limited range. These results suggest that PIC BE is an effective anti cancer compound, and K 562 /ADM cell line with MDR has no resistance to it.
【Fund】: 国家自然科学基金资助项目!(No. 391 70 85 3)
【CateGory Index】: R965
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