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《Chinese Journal of Histochemistry and Cytochemistry》 2007-01
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EFFECT OF PLUS SIJUNZI DECOCTION ON ERK-SIGNAL TRANSDUCTION MATTERS IN RAT MODEL OF Pi-Xu SYNDROME COMBINED WITH GASTRIC ULCER

Du Juan, Wang Xiuqin, Ji Fengqing, Zeng Xiaobei, Sun Haimei, Li Baohong(Department of Histology and Embryology, Capital University of Medical Sciences, Beijing 100054, China) ;  
Objective To study the role of 'plus sijunzi decoction’ in the healing of experimental Pi-Xu syndrome combined with gastric ulcer. Methods Using hematoxylin-eosin staining, immunohistochemical technique, and Western-blotting to show the gastric mucosa structure, the phosphorylation level of ERK2 in the gastric mucosa, and the contents of EGF in the granular convoluted tubule (GCT) cells of the submandibular glands respectively. Results After treatment with 'plus sijunzi decoction’, the phosphorylation level of ERK2 in the gastric mucosa decreased, and the contents of EGF in the GCT cells of the submandibular glands increased in contrast to the control group respectively. The recovery of gastric ulcer was accelerated. However,little change was found in spontaneously recovering group. Conclusion 'Plus sijunzi decoction’ accelerates the healing of pi-xu syntrom combined with gastric ulcer by mechanisms involving the increased release of EGF from the submandibular glands and the consequent up-regulation of p-ERK2 in the gastric mucousa.
【Fund】: 北京市中医药管理局科技发展基金资助项目(JJ-2001-32)
【CateGory Index】: R285.5
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1 CHEN Tian\|e, WANG Xiou\|qin * , ZHANG Hua, LI Bao\|hong,ZENG Xiao\|bei,SUN Hai\|mei (Department of Histology and Embryology, Capital University of Medical Science, Beijing\ 100054,China) \;[;STUDY OF IMMUNO-NEUROENDOCRINE NETWORK CHANGES IN LOCAL GASTROINTESTINAL MEMBRANE DURING SPLEEN-DEFICIENCY SYNDROME COMBINED WITH GASTRIC ULCER IN RATS[J];Acta Anatomica Sinica;2003-04
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1 Zhao Suxian 1,Wang Xiuqin,Du Juan,Zeng Xiaobei,Li Baohong,Sun Haimei(Department of Histology and Embryology,Capital University of Medical Sciences,Beijing 100069;1Academy of Militalry Medical Sciences,Beijing 100850,China);CHANGES OF 5-HT AND ITS REPTOR IN RAT COLON TISSUE OF SPLEEN-DEFICIENCY COMBINED WITH GASTRIC ULCER[J];Chinese Journal of Histochemistry and Cytochemistry;2006-05
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