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《Chinese Journal of Histochemistry and Cytochemistry》 2007-03
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DISTRIBUTION OF ANDROGEN RECEPTORS AND THEIR MODULATION BY CADMIUM AND TESTOSTERONE IN MALE RAT SUBMANDIBULAR GLAND

Li Xinzhi,Liao Xiaogang(Laboratory of Electron Microscopy,Chongqing Medical University,Chongqing 400016,China)  
Objective To investigate the expression of androgen receptors(AR) in male rat submandibular gland and their modulation by cadmium(Cd) and testosterone(T).Methods Thirty-five male adult Wistar rats were randomly divided into three groups: control,Cd and Cd + T.The expression of AR was detected by immunohistochemistry(SABC) and semi-quantitatively analysed by image analysis. Results Specific immunoreactivity of AR in the submandibular gland appeared mainly in the plasma of cells in acini(AC),granular convoluted tubule(GCT),striated duct(SD) and excretory duct.The average optical density(AOD) of AR was highest in GCT cells,medial in SD cells,and lowest in AC cells.The AOD of AR decreased at 24h after Cd treatment,reached the lowest level at the 7th day,and partly restored at the 30th day.The AOD of AR in GCT cells in the Cd+T group was significantly increased than that in the Cd group at the 3th,7th and 15th day;however,the AOD of AR in acini and striated duct in the Cd+T group was significantly increased only at the 7th day.Conclusion The expression of AR in GCT,AC and SD cells was downregulated by Cd,but upregulated by androgen.The expression of AR and the up-regulation in GCT cell was stronger than that in AC and SD cells.
【Fund】: 重庆市高校优秀中青年骨干教师资助计划(渝教人 [2002]17号)
【CateGory Index】: R363
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【Citations】
Chinese Journal Full-text Database 6 Hits
1 Xu Chen,Li Weixin △ (Laboratory of Electron Microscopy,Chongqing University of Medical Sciences,Chongqing);THE EFFECTS OF CADMIUM ON ULTRASTRUCTURE AND TPPase CYTOCHEMISTRY OF SEMINAL VESICLE AND SERUM CONCENTRATION OF TESTOSTERONE IN RATS[J];ACTA ANATOMICA SINICA;1997-03
2 Bing YAO, Jun FAN, Yong Mei WANG, Ying Xia CUI, Yu Feng HUANG (Laboratory of Reproduction & Genetics,Nanjing General Hospital of Nanjing Command, PLA,Nanjing,Jiangsu 210002,China);The Distribution of Androgen Receptor and Its Coexistence with Gonadotropin Releasing Hormone Receptor in Rat Submaxillary[J];Acto andrologica Sinica;2002-01
3 ZHU Yun-feng Clinical Laboratory,Zhangjiagang Hospital of Chinese Traditional Medicine,Zhangjiagang,Jiangsu 215600,China;Castration Affects the Expression of Androgen Receptor and Epidermal Growth Factor in Rat Submaxillary Salivary Gland[J];National Journal of Andrology;2006-06
4 Liao Xiaogang, Li Weixin (Laboratory of Electron Microscopy, Chongqing University of Medical Sciences, Chongqing, 400046);Morphological Study of Injurious Action of Cadmium and Protection of Zinc on Rat Leydig Cells[J];REPRODUCTION AND CONTRACEPTION;1999-05
5 LI Xin-zhi, LIAO Xiao-gang;Advanced studies of effect of androgen and its receptor on submandibular gland of male animals[J];Journal of Reproductive Medicine;2004-06
6 LI Xinzhi,et al(Laboratory of Electron Microscopy,Chongqing Medical University);Effects of cadmium on submandibular gland and the protective effects of testosterone in male rats[J];Journal of Chongqing Medical University;2006-04
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 LIANG Zhu-min et al (Guangxi Agricultural College of Professional Technology,Nanning,Guangxi 530007);Study on the Optimal Age of Castration in Suckling Boar[J];Journal of Anhui Agricultural Sciences;2007-22
2 ZHAO Rong, LI Ling \ Department of Human Parasitology, Qingdao University Medical College, Qingdao 266021\;;INFLUENCE OF ALCOHOL OVERTAKING ON THE ULTRAMICROSCOPIC STRUCTURE OF THE TESTIS[J];Acta Acadimae Medicinae Qingdao;2002-03
3 WANG Lan ①** SUN Hai Feng ② LI Chun Yuan ③ (① College of Life Science and Technology, Shanxi University, Taiyuan 030006, Shanxi, China) (② Collleg of Chemistry Engineering, Shanxi University, Taiyuan 030006, Shanxi, China) (③ Ch;EFFECTS OF CADMIUM ON SPERMATOGENESIS IN FRESHWATER CRAB (SINOPOTAMON YANGTSEKIENSE)~*[J];Acta Zoologica Sinica;2002-05
4 LI Xin-zhi1,LIAO Xiao-gang2(1.Department of Anatomy and Histo-embryology,Chengdu Medical College,Chengdu 610083,China;2.Laboratory of Electron Microscopy,Chongqing Medical University,Chongqing 400016,China);The Effects of Cadmium on Ultrastructure of Submandibular Gland and the Protective Effects of Testosterone in Male Rats[J];Journal of Chengdu Medical College;2007-02
5 LI Xia,WANG Qiu-shi, LI Ou(Key Laboratory of Mariculture & Biotechnology,Agriculture Ministry,PRC,Dalian Fisheries Univ.,Dalian 116023,China);The effects of cadmium on spermatogenesis in sea urchin Strongylocentrotus intermedius[J];Journal of Dalian Fisheries University;2007-05
6 JIANG Yan-qiong1,WANG Jia-yue1,TANG Si-xian1,LU Yi-wei1,HAO Jia2 (1.School of Life Science,East China Normal University,Shanghai 200062,China;2.Fishery Technical Extension Center,Dalian 116021,China);Toxicity Effect of Cadmium on the Testicular Tissue of Coturnix coturnix japonica[J];Journal of Fudan University(Natural Science);2007-06
7 QIU Ji(Office of Scientific Research,Huzhou Vocational& Technological College,Huzhou 313000,China);Review of the Male Reproductive Toxicity by Cadmium[J];Journal of Huzhou Vocational and Technological College;2008-03
8 LUO Zi\|guo *, LI Wei\|xin (Laboratory of Electron Microscopy, Chongqing University of Medical Sciences, Chongqing\ 400016, China);THE INJURIOUS EFFECTS OF CADMIUM AND PROTECTION OF ZINC ON ULTRASTRUCTURE AND CYTOCHEMISTRY OF TPPase OF PROSTATE IN RAT[J];ACTA ANATOMICA SINICA;2000-04
9 Lei Lei CHEH, Bing YAO, Yu Feng HUANG (Laboratory of Reproduction & Genetics, Nanjing General Hospital of Nanjing Command, PLA, Nanjing, Jiangsu 210002, China);The Distribution and Detection of Androgen Receptor in Extra-testis Tissues[J];Acto andrologica Sinica;2003-01
10 Qi Lu XU (The Nankong Official Hospital of Nanjing, Nanjing, Jiangsu 210002, China);The Localization and Potential Function of Androgen Receptor mRNA in Rat Submaxillary[J];Acto andrologica Sinica;2003-09
China Proceedings of conference Full-text Database 1 Hits
1 JIANG Yan-qiong~1 WANG Jia-yue~1 TANG Si-xian~1 LU Yi-wei~1 HAO Jia~2 (1.School of Life Science,East China Normal University,Shanghai 200062,China; 2.Fishery Technical Extension Center,Dalian 116021,China);Toxicity Effect of Cadmium on the Testicular Tissue of Coturnix coturnix japonica[A];[C];2008
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 YAO Bing 1, SUN Xiu De 2, WANG Yong Mei 1, CUI Ying Xia 1, HUANG Yu Feng 1, HU Yu Hong 3 1Department of Genetics & Reproduction, 3Laboratory Center of Animal, Nanjing General Hospital, Nanjing Military Area Command of Chinese PLA, Nanjing 210002, China, 2Department of Anaesthesia, Tangdu Hospital, Fourth Military Medical University, Xian 710038, China;The localization and quantity analysis of FasL in submaxillary of rat with testis removed[J];Journal of The Fourth Military Medical University;2002-24
2 Yao Bing, Huang WeiQuan, Pu RuoLei, * Zhang RongQing, * Wang Lei (Department of Histology and Embryology of Fourth Military Medical University, Xian 710032 Department of Biology of Tsinghua University, Beijing 100084, China);RT-PCR AND IN SITU HYBRIDIZATION STUDY OF GONADOTROPIN RELEASING HORMONE RECEPTOR mRNA IN RAT SUBMAXILLARY[J];Chinese Journal of Histochemistry and Cytochemistry;2000-04
3 YAO Bing 1, HUANG Wei\|quan 1* , ZHANG Rong\|qing 2, WANG Lei 2 (1 Department of Histology and Embryology of the Fourth Military Medical University, Xian\ 710032,China; 2 Department of Biology of Tsinghua University, Beijing\ 100084, China) \;;AMPLIFICATION SEQUENCE ANALYSIS OF GnRH RECEPTOR GENE IN RAT SUBMAXILLARY GLAND[J];Acta Anatomica Sinica;2001-01
4 Xu Chen,Li Weixin △ (Laboratory of Electron Microscopy,Chongqing University of Medical Sciences,Chongqing);THE EFFECTS OF CADMIUM ON ULTRASTRUCTURE AND TPPase CYTOCHEMISTRY OF SEMINAL VESICLE AND SERUM CONCENTRATION OF TESTOSTERONE IN RATS[J];ACTA ANATOMICA SINICA;1997-03
5 Liao Xiaogang △,Li Weixin (Laboratory of Electron Microscopy,Chongqing University of Medical Sciences,Chongqing);ULTRASTRUCTURAL AND AlPase CYTOCHEMICAL STUDIES OF INJURIOUS ACTION OF CADMIUM AND PROTECTION OF ZINC AND VITAMIN E ON RAT EPIDIDYMIDES[J];ACTA ANATOMICA SINICA;1997-03
6 Tang Xianghui △,He Xiechao,Zhou Zengdi *,Li Mannong *,Chen Yunhe (Kunming Institute of Zoology,CAS,Kunming; *Yunnam Province Family Planning Institute);NUMBER CHANGE OF EPIDIDYMIS SPERM IN MICE AFTER SIALOADENECTOMY[J];ACTA ANATOMICA SINICA;1998-02
7 Liu Linai;Liu Chuan;Hua Zongwei Institute of Basic Medical Sciences,Academy of Millitary Medical Sciences,Beijing 100850;THE EFFECT OF MALE SEXUAL HORMONE ON THE SYNTHESIS OF NERVE GROWTH FACTOR IN DEVELOPING MOUSE SUBMANDIBULAR GLANDS[J];Chinese Journal of Anatomy;1993-02
8 Bing YAO, Yu-Feng HUANG (Laboratory of Reproduction & Genetics, Nanjing General Hospital of Nanjing Command, PLA, Nanjing, Jiangsu 210002, China);The Distribution and the Potential Function of Epidermal Growth Factor and Its Receptor in Testes[J];Acto andrologica Sinica;2001-04
9 Jun Qiao YU 1, Ji Chun SHAO 2, Zheng Guang ZENG 2 (1. Chengdu University of Traditional Chinese Medicine, Chengdu,Sichuan 610075, China; 2. the Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610072, Ch;The Influence of Epidermal Growth Factor and Its Receptor on Male Reproductive System[J];Acto andrologica Sinica;2001-05
10 Bing YAO, Jun FAN, Yong Mei WANG, Ying Xia CUI, Yu Feng HUANG (Laboratory of Reproduction & Genetics,Nanjing General Hospital of Nanjing Command, PLA,Nanjing,Jiangsu 210002,China);The Distribution of Androgen Receptor and Its Coexistence with Gonadotropin Releasing Hormone Receptor in Rat Submaxillary[J];Acto andrologica Sinica;2002-01
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