Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Histochemistry and Cytochemistry》 2007-05
Add to Favorite Get Latest Update


Zhu Wei,Li Zhengli,Zhu Changgeng,Yao Zhifang,Wang Xiaojing(Department of Anatomy,Tongji Medical College,Huazhong University of Secience and Technology,Wuhan 430030,China)  
Objective To explore the role of immunoregulator in epileptogenesis.Methods PTZ(pentylenetetrazol) was used to induce epilepsy,LMZ(levamisole) and DXM(dexamethasone) were used as immunoenhancer and immunodepressor respectively to interfere in the occurrence of epilepsy.The rats were randomly divided into 4 groups:NS(control)group,PTZ group,LMZ+PTZ group,and DXM+PTZ group.After treatment with relevant reagents,the behaviour was observed,the expressions of NMDAR1 and NF-κB in the cerebral cortex and hippocampus of rats were examined by means of immunohistochemistry.Results The behaviour observation indicated that no seizure happened in the control group,but Ⅲ-Ⅳ grade of seizure in the PTZ group and Ⅴ grade in the LMZ+PTZ group,and Ⅰ-Ⅱ grade in the DXM+PTZ group occured.Immunohistochemical staining showed that there were expressions of NMDAR1 and NF-κB in the cerebral cortex and hippocampus of all groups.The same tendency of changes for the two indices was observed.The expressions of NMDAR1 and NF-κB p65 in the PTZ group were higher than that in the NS group,and the expressions were further enhanced in the LMZ+PTZ group compared with those of the PTZ group,while they were lower in the DXM+PTZ group than in both PTZ and LMS+PTZ groups.There were significant differences in NMDAR1 and NF-κB immunoreactivities among the four groups.Conclusion Immunoenhancer or immunodepressor could up-regulate or down-regulate the expression of NMDAR1 and the activation of NF-κB could interfere the occurrence and development of epilepsy.
【Fund】: 湖北省自然科学基金(2004ABA196)
【CateGory Index】: R742.1
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 2 Hits
1 Zhu Changgeng Δ,Liu Qingying,Wei Ying,Ma Chunling, Hao Jiandong, Yan Ping (Department of Anatomy,Tongji Medical University,Wuhan);GOEXISTENCE OF IMMUNE NEURO ENDOCRINE SUBSTANCES IN THE RAT CENTRAL NEURONS[J];ACTA ANATOMICA SINICA;1999-02
2 WANG Qun, RUAN Xu zhong, SHI Ting hui, ZHANG Su ming, ZHU Chang geng (Department of Neurology, Tongji Hospital, Tongji Medical University, Wuhan 430030);The dynamic alterations of NMDA receptor subunit 1 mRNA in rat cerebral cortex and hippocampus of seizure rats induced by coraria lactone[J];Chinese Journal of Neuroscience;2000-01
Chinese Journal Full-text Database 7 Hits
1 Pan Sangqiang,Su Baogui,Lu Laiqing,Han Hui,Yao Junru. Department of Anatomy,Medical College of Jinan University,Guangzhou,510632,China;Change of protein kinase C positive neurons of hippocampus formation in rats by pentylenetetrazol kindling[J];Anatomy Research;2002-02
2 HAN Hui,SU Bao-gui,PAN San-qiang,LU Lai-qing (Dept. of Anatomy, Medical College, Jinan University, Guangzhou 510632, China) ;The distribution of protein kinase C positive cells in the cerebral cortex and hippocampus formation of rats[J];Journal of Jinan University(Natural Science & Medicine Edition);2003-02
3 LI Zheng\|li * , ZHU Chang\|geng, WEI Ying (Department of Anatomy of Tongji Medical College, Huazhong University of Science and Technique, Wuhan\ 430030,China);COEXISTENCE OF INTERLEUKIN-2 AND GLUCOCORTICOID RECEPTORS IN THE BRAIN NEURONS[J];Acta Anatomica Sinica;2001-04
4 ZHANG Qing\|hong\+*, HU Yu\|zhen, CHEN Ya\|qiong, ZHANG Wan\|hui, CHEN Jian\|kang, WANG Fu\|zhou (Department of Physiology, the Fourth Military Medical University, Xi′an\ 710032, China);COEXISTENCE OF SOME IMMUNE-ENDOCRINE SUBSTANCES IN THE RAT ANTERIOR PITUITARY[J];Acta Anatomica Sinica;2001-04
5 Wang Hongjuan1,2,Zhao Zhiwei1,Ji Zhijuan1,Sheng Shuli1,Wang Rong1(1.Department of Neurobiochemistry,Xuanwu Hospital, Capital Medical University;Key Laboratory for NeurodegenerativeDisease of Ministry of Education;2.Yanjing Medical College,Capital Medical University);Coexistence of AD7c-NTP and Insulin Receptor in CA1 Zone of Hippocampus in Mouse[J];Journal of Capital Medical University;2007-03
6 Li Zhengli, Zhu Changgeng, Wei Ying et al Department of Anatomy, School of Basic Medical Sciences, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030;Coexistence of Interleukin-2 Receptor, Progesterone Receptor and Metabotropic Glutamate Receptor Subunit 5 in Neurons of Hypoglossal Nucleus[J];Acta Universitatis Medictnae Tangji;2002-04
7 SUO Yu-ping,WANG Bao-ying,WANG Dan-qing,WANG Xiu-xia.Department of Obstetrics and Gynecology,the People′s Hospital of Shanxi Province,Taiyuan 030012,China;Effect of KunNingAn on estrogen receptor and mRNA in hypothalamus of perimenopause syndromes rats[J];Chinese Remedies & Clinics;2006-08
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved