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《Chinese Journal of Histochemistry and Cytochemistry》 2009-03
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EXPRESSION AND SIGNIFICANCE OF ERK1/2 AND P-ERK1/2 IN HUMAN LUNG CANCER

Gu Yanjiao1,Bao Cuifen2,Weijia2,Liangjia2,Gao Zhian1(1Department of Pathology,The First Affiliated Hospital;2Center of Scientific Experiment,Liaoning Medical college,Jinzhou 121000,China)  
Objective To detect the expression of ERK1/2 and p-ERK1/2 in different lung cancer and research the relationship between the two factors and the lung cancer.Methods The expression of ERK1/2 and p-ERK1/2 in different human lung cancers were detected by immunohistochemistry techniques.Results The expression of ERK in the poorly,moderate and well differentiated groups was 13.6%,39.4% and 66.7%,respectively,while the expression of p-ERK1/2 was 14.3%,27.3% and 79.2%(P0.05).The positive rate was 51.3% in cases with lymph node metastasis and 20% in those without.The expressions of ERK1/2 and p-ERK1/2 proteins were related with differentiation degree of lung cancer,but not with sex,age,pathological type and site or size of tumor;and the expression of p-ERK1/2 was also related with Lymph node metastasis.Conclusion ERK1/2 and p-ERK1/2 protein expressed more in different human lung cancer,they may play important roles in the occurrence and development of lung cancer.
【CateGory Index】: R734.2
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