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Zhu Dingshou, Shi Xiaolin, Liang Yuanjing, Weng Jing, Xu Qin, Lu Xin (Reproductive Medical Center, Capital University of Medical Sciences, Beijing 100054)  
Progesterone receptors in the ovaria, fallopian tubes, uteri and vaginas of female mice were studied by immunocytochemical LSAB method, using rabbit antihuman-progesterone-receptor IgG. In normal mice, progesterone receptors distributed mainly in uteri and vaginas, only a few in fallopian tubes, and none in ovaria. 4 days after the injection of RU486 the number of the receptors in uteri and vaginas reduced obviously. 7 days after injection, all tissues appeared negative reaction. This data showed the specific distribution of progesterone receptor in female mouse reproductive system and indicated that the best time for RU486 blocking progesterone receptor was the 7 th day after injection.
【Fund】: 国家自然科学基金,北京市自然科学基金
【CateGory Index】: S852
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