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《CHINESE JOURNAL OF HISTOCHEMISTRY AND CYTOCHEMISTRY》 1999-02
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EFFECTS OF PERINDOPRIL ON VASCULAR HYPERTROPHY IN RAT WITH EXPERIMENTAL HYPERTENSION

Tang Jiarong, Liu Zhengxiang, Zhou Qiang, Zhang Jing *, Wu Cuihuan ** , Liang Qianshen (  Department of Cardiology, Tongji Hospital, Department of Neurobiology,  Department of Pathology, Tongji Medical University, Wuhan, 430030  
The model of hypertensive rat was established by using the method of abdominal aortic constriction. 33 male SD rats were randomly divided into 4 groups: group A (sham operated rats serving as controls), group B (hypertensive rats serving as controls), group C hypertensive rats subjected to low dose perindopril treatment, 0 1 mg/kg -1 /d) and group D (hypertensive rats receiving high dose perindopril treatemnt, 1 5 mg/kg -1 /d). The drug was administered by gavage for 4 weeks. At the end of the treatment, mean arterious pressure (MAP) was measured via catheter in the carotid artery. The ratio of medial thickness to diameter of lumen of aotra and superior mesenteric artery was calculated by morphometry. Our results showed that perindopril, both high dose and low dose, may prevent hypertrophy of the tunica media of superior mesenteric artery. In addition, high dose perindopril may significantly inhibit hypertrophy of aortic media. The above effects of perindopril may be explained by inhibition on tissue angiotension Ⅱ(AⅡ) of vascular wall, but is not related to circulating A Ⅱ(PAⅡ).
【CateGory Index】: R311.32,R311.32
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