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《高等学校化学研究(英文版)》 2012-05
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Chitosan-graft-poly(L-glutamic acid) Hybrid Material and Its Self-assembly

LIU Ye-zhuo, YAO Jin-rong*, CAO Heng, LENG Bo-xun, SHAO Zheng-zhong and CHEN Xin* State Key Laboratory of Molecular Engineering of Polymers, Laboratory of Advanced Materials, Department of Macromolecular Science, Fudan University, Shanghai 200433, P. R. China  
Chitosan-graft-poly(L-glutamic acid)(CS-g-PGA) copolymer was successfully synthesized by grafting polymerization of γ-benzyl-L-glutamate N-carboxyanhydride onto the modified chitosan chains. The self-assembly behavior of such a CS-g-PGA amphiphilic copolymer was studied. The results show that spherical nanoparticles have been formed. The size of CS-g-PGA nanoparticles is found to be controlled by the grafting ratio of PGA. These bio-based polysaccharide/polypeptide hybrid nanoparticles with controllable size may have great potential application in biomedical fields, such as drug delivery systems.
【Fund】: Supported by the National Natural Science Foundation of China(Nos.21034003 20974025 10979022)
【CateGory Index】: O631.3
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