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《Chinese High Technology Letters》 2007-12
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The methylation modification accompanying X chromosome inactivation

Li Yan, Liang Qianjin, Tao Wei (College of Life Sciences, Beijing Normal University, Beijing 100875) (College of Life Sciences, Peking University, Beijing 100871)  
X chromosome inactivation (XCI) is the manner to achieve dosage compensation of genes on X chromosomes in mammals. XCI is controlled by the key regulation factor——Xist RNA that coats the X chromosome in cis and triggers its silencing. The inactivated X chromosome (Xi) is characterized by a series of epigenetic modifications, including histone H3 methylation, histone H3 and H4 hypoacetylation, enrichment of variant histone macroH2A and DNA methylation, which play a key role during X chromosome inactivation. Histone H3 Lys-9 methylation and H3 Lys-27 methylation are two unique repressive marks, and required in the establishment and maintenance of XCI. DNA methylation also plays an essential role in the maintenance of XCI. Here we describe the modification of methylation in XCI in detail.
【Fund】: 国家自然科学基金(30470875 30270081)资助项目
【CateGory Index】: Q343
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