Effect of acathopanax senticosus on the level of glutamate and NO on the retina in high ocular pressure models
Dian-Wen Gao, Li Shao, Yang Yang Department of Ophthalmology, the Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China
AIM: To discuss the neuropertection and mechanism of AS to acute ischemia-reperfusion rats. METHODS: Sixty-nine Wistar rats were divided randomly into three groups: 5 in normal group, 32 in AS group and 32 in ischemia-reperfusion group. Intraocular pressure was raised to 100 mmHg by elevating the normal saline container lasting for 60 minutes. Then, reperfusion of the retinal vascular was undergone. AS with 100 mg/kg was intraperitoneal injected to the rats in AS group six hours before ischemia management and AS rats were given drugs everyday until death. The rats in control group were injected with same volume normal saline. Six, 24, 48, and 72 hours after reperfusion,, 8 rats were sacrificed and their eyes were estimated of the level of Glu and NO. RESULTS: By comparing with the normal group, Glu levels were all increased in ischemia-reperfusion group (P0.01). Glu and NO level reached their peak at 48 hours. NO levels of were much higher than that in normal group (P0.05). CONCLUSION: AS can decrease the Glu and antagonize Glu produce NO, decrease the damage of ischemia-reperfusion in retina.
【CateGory Index】： R285.5