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《International Journal of Ophthalmology》 2007-01
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Effect of elemene and/or etoposide on the expression of survivin and apoptosis of retinoblastoma HXO-RB44 cells

Wei Wei, Luo-Sheng Tang, Li Li, Yi-Tao Yang, Wen-Jun Wang Department of Ophthalmology, Xiangya Second Hospital, Central-South University, Changsha 410011, Hunan Province, China  
· AIM: To investigate the effects of elemene and/or etoposide on the apoptosis of human retinoblastoma HRO-RB44 cell and the expression of survivin in vitro. · METHODS: The HRO-RB44 cells were treated with elemene and/or etoposide for 24 hours, and then the proliferation was assessed by MTT method. The survivin expression were analyzed by flow cytometry and RT-PCR. · RESULTS: Elemene and etoposide could inhibit the growth of HXO-RB44 cells, down-regulate the expression of survivin, and induce extensive apoptosis of HRO-RB44 cell. · CONCLUSION: Elemene could enhance the effects of etoposide on proliferative suppression, survivin expression down-regulation, and apoptosis induction of HRO-RB44 cells. ·
【CateGory Index】: R739.7
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