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《International Journal of Ophthalmology》 2007-01
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Reliability of evaluating grade of diabetic retinopathy from non-stereoscopic color fundus photographs

Zhe Chen1,Nikawa Tatsuya1,Ping Xu2,Hirosaki Shinji1,Hao Yan1 1Fundus Photograph Reading Center,The Clinical Service Provider,EPS Co.,Ltd.,Japan;2EPS China Co.,Ltd.,Shanghai 200030,China  
· AIM:To determine the reliability of evaluating grading for diabetic retinopathy(DR)from color fundus photographs and related factors.· METHODS:The raters consisted of 13 graders were non-ophthalmologists who had been trained extensively to assess diabetic retinopathy and one senior grader was a professor of DR.The intra-observer,inter-observer and accuracy reliability of stage-evaluation for DR using ETDRS's classification was assessed by theκcoefficient.Intraclass correlation coefficient.The study was a double-blind,randomized trial,presenting the methodology for 4-fields 500 fundus photography and details for the assessment of DR.This system provided more steps in the grading scale for 11 characteristics(Haemorrhages and Micro-Aneurysms,Hard Exudates,and so on).· RESULTS:Retinopathy data from completed grading forms were computerized at the Coordinating Centre using SAS(should give version number).Theκcoefficient was calculated to evaluate the intra-observer reliability,was 0.49 to 1.00(Mean value:0.81-0.93).Theκto evaluate the inter-observer for the 1st was 0.41 to 1.00(Mean value:0.70-0.90)and that for the 2nd time was 0.37 to 1.00(Mean value:0.63-0.89);The κ of Accuracy reliability for the 1st was 0.45 to 1.00(Mean value:0.79-0.95),κw:0.52-1.00(Mean value 0.86-0.98)and that for the 2nd was 0.37 to 1.00(Mean value:0.79-0.95),κw:0.43-1.00(Mean value 0.84-0.98).· CONCLUSION:Our results suggest high reliability of evaluation grade of DR and the necessarily of the standardization of DR using fundus photographs.·
【Fund】: 日本厚生省科研项目~~
【CateGory Index】: R774.1
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