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《International Eye Science》 2012-07
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Ginkgo biloba extract inhibits the proliferation of human pterygium fibroblasts in vitro

Jing Zhu,Chao-Qiong Wu,Dan Chen Department of Ophthalmology,the First Hospital of Wuhan,Wuhan 430022,Hubei Province,China  
AIM:To investigate the effects of ginkgo biloba extract(GBE) with different concentration on the proliferation of human pterygium fibroblasts cells(HPFs).METHODS:The HPFs were incubated with GBE at concentration of 12.5mg/L,25.0mg/L,50.0mg/L,100.0mg/L for 24-72 hours,the effects of GBE on the proliferation of HPFs were evaluated by MTT assay.Flow cytometry(FCM) was used to examine the cell cycle distribution and apoptosis of HPFs exposed to different concentrations of GBE for 48 hours.RESULTS:The proliferation of HPFs was not significantly inhibited incubated with 12.5mg/L GBE for 24 hours through MTT assay(P0.05).Other groups could significantly inhibit HPFs proliferation in a dose-and time-dependent manner,and there were significant differences between each of the two groups(P0.05).Flow cytometry examination suggested the cell percentage in the G0/G1 phase increased while that of the S phase decreased exposed to different concentrations of GBE for 48 hours,the rate of apoptosis of HPFs respectively reached 4.37%,8.14%,11.09%,15.18%,and there were significant differences between the two groups(P0.05).CONCLUSION:GBE can significantly inhibit HPFs proliferation and induce its apoptosis with dose-and time-dependent manner.
【Key Words】: pterygium fibroblasts cells proliferation inhibition
【CateGory Index】: R777.33
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 WANG Dan1,2,LI Xiangjun1,YU Xiaoyan1,SHI Yan1,YIN Li1(1.Department of Experimental Pharmacology and Toxicology,School of Pharmacy,Jilin University,Changchun 130021,China;2.Department of Pathology,School of Basic Medical Sciences,Beihua University,Jilin 132001,China);Expression of tissue transglutaminase on renal interstitial fibrosis rats and intervention of GBE[J];China Journal of Chinese Materia Medica;2009-09
【Co-citations】
Chinese Journal Full-text Database 4 Hits
1 He Cai,Wang Xuan,Deng Mingming△,Zhou Zhengduan,Liu Hong,Qu Xiaoping(Department of Gastroenterology,the First People′s Hospital of Yibin City,Sichuan 644000,China);The study on the protective effect and mechanism of ginkgo extract to the kidney injury of rats with SAP[J];Chongqing Medicine;2011-29
2 GUAN Jinju1 CHEN Huanhuan1 ZHAO Yan2 1.Center of Labortory Medicine,Zhejiang Provincial People's Hospital,Hangzhou 310014,China;2.Department of Cardiology,Zhejiang Provincial People's Hospital,Hangzhou 310014,China;Clinical significance of platelet activation factor and von Willebrand factor in patients with unstable angina pectoris accepting Ginkgo Biloba tablet treatment[J];China Modern Doctor;2012-23
3 Ni Na,Kang Yunping,Xu Hao,Liu Yunxia.Hangzhou Third People′s Hospital,Zhejiang 310009,China;Effects of Tianbaoning Tablet on Platelet Activation Factor,von Willebrand Factor and Platelet Aggregation Rate in Patients with Essential Hypertension[J];Journal of Medical Research;2012-10
4 YIN Qi-Gai,SUN Lin-Xia,LI Shan,et al.Department of Pediatrics,the First People's Hospital of Lianyungang,Lianyungang 222000,Jiangsu,China;Effect of Ginkgo biloba extract on the expression of matrix metalloproteinase in the hypoxic ischemic brain damage[J];Maternal and Child Health Care of China;2013-21
【Secondary Citations】
Chinese Journal Full-text Database 2 Hits
1 LI Xiang-jun,LI Cai,SUN Guang-dong,MIAO Chun-sheng,SUN Bo(Department of Pathology,Institute of Frontier Medical Scinces,Jilin University,Changchun 130021,China);Protective effect of Ginkgo biloba tablet on rat kidney with unilateral ureteral obstruction[J];Journal of Jilin University(Medicine Edition);2007-01
2 Jian-Jun Yan1,Hui-Can Peng1,Yu-Fang Wang1,Cheng-Xiang Wu2,Zhao-Yao Liu11 Department of Ophthalmology,the Second Affiliated Hospital of Nanhua University,Hengyang 421001,Hunan Province,China;2 Hunan Traditional Chinese Medical College,Zhuzhou 412012,Hunan Province,China;Effects of ginkgo biloba extract on proliferation and apoptosis of human retinal capillary endothelial cells in high glucose environment[J];International Journal of Ophthalmology;2008-12
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