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《International Medicine & Health Guidance News》 2003-10
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Inquiring relation between methylene tetrahydrofolate reductase (MTHFR) gene polymorphysm andthe Alzheimer desease

Liu xuejun zhanghuiwen Chen ShengqiangGuangzhou Brain hospital  
Objective To study the distribution of methylene tetrahydrofolate reductase(MTHFR) gene in patients with Alzheimer desease , and analyse the relation between them. Method MTHFRgenotyes of patients with Alzheimer desease and age-matched healthy controls were determined by usingthe polymerphism technique,subsequently to require the ratation between MTHFR allele and AD. ResultsMTHFR T allele of patients obviously was higher than cotrols, but MTHFR C allele of patients waslower than cotrols.CONCLUSIONS:The C677T methylenetetrahydrofolate reductase mutation is associatedwith Alzheimer's disease.Conclusion In ApoE allele , ?4 allele is a genetic suscetible factor inADandACI, ?3 allele is a protection factor.
【CateGory Index】: R749.16
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【Citations】
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【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 XU En, DENG Bing-mei, CHEN Shen-qiang, XIE Hai-feng, LU Xue-fen. Department of Neurology, the Second Affiliated Hospital of Guangzhou Medical College, Guangzhou, 510260, China.;The relationship between gene polymorphisms of MTRR A66G, MS D919G, MTHFR C677T and cerebral infarction[J];Chinese Journal of Neuromedicine;2005-09
2 WANG Gang-hua,ZHENG Mei-ling.(Laboratory of Genetics,Department of Gynecology and Obstetrics,the First Affiliated Hospital,Shanxi Medical University,Taiyuan 030001,P.R.China)Corresponding author: WANG Gang-hua.E-mail: wgh791125@163.com;Advances in Researches between Genes Related to Homocysteine Metabolic and Neural Tube Defects[J];International Journal of Genetics;2006-01
3 LIANG Jian-ning1 ,CHEN Sheng-qiang2(1. People's Hospital of Xinhui City,2. Research Institute of Neuroscience , Guangzhou Medical College);Detection of the Methyltetrahydrofolate Reductase Gene in 143 Individuals[J];Academic Journal of Guangzhou Medical College;2002-01
4 PAN Qi, GUO Li-Xin, CHU Ming-Feng, MAN Yong, SUN Ming-Xiao, LI Ming, and LIU Xiao-Ping(1.Department of Endocrinology of Beijing Hospital, 2.Beijing Institute of Geriatrics Ministry of Public Health, Beijing 100730, China);Relationship between Genetic Polymorphisms of Homocysteine Metablism Related Enzymes and Carotid Intima-Media Thickness in Type 2 Diabetic Patients[J];Chinese Journal of Arterial Lerosis;2005-02
5 XIAO Yan,HU Zhi-heng,SHAN Ke-ren,et al.The Key Laboratory of Molecular Biology in Guiyang Medical University,Guiyang 550004,China;Study on the polymorphysm of MTHFR gene in coronary heart disease in Guizhou[J];Chinese Journal of Practical Internal Medicine;2007-04
6 WANG Lin,GUO Hong,LI YumingSecond Hospital of Tianjin Medical University,China 300211;MTHFR Gene C 677 T Polymorphisms and Variation of Plasma Homocysteine Levels in Primary Hypertension[J];Tianjing Medical Journal;2002-10
7 Liu Na,Yang Zhi jie,Fan Dong sheng Liu Na,Yang Zhi jie,Fan Dong sheng,Department of Neurology, Third Hospital o f Peking University, Beijing 100083,China;Correlation between the decline of cognitive function and the level of plasma homocysteine in patients with Alzheimer disease[J];Chinese Journal of Clinical Rehabilitation;2005-01
8 Chen YL,Zhang XY,Xu XJ,Wu GZ,Zou JP,Shi XK,Zhang Y,Wang H,Askar 1Cardiovascular Specialized Hospital of First Affiliated Hospital,Xinjiang Medical University,Urumchi 830054,Xinjiang Uygur Autonomous Region,China; 2Department of Biochemistry,Basic Medical College,Xinjiang Medical University,Urumchi 830054,Xinjiang Uygur Autonomous Region,China;Correlation of the polymorphism of methylene tetrahydrofolate reductase gene and plasma homocysteine with coronary heart disease in Uygur and Han ethnic groups in Xinjiang[J];Journal of Clinical Rehabilitative Tissue Engineering Research;2007-17
9 Ran ZX, Chen YL, Zhang XY, Xu XJ, Wu GZ, Zou JP, Shi XK 1Department of Internal Medicine, 66th Corps of No. 4 Agricultural Division of Xinjiang, Huocheng 835219, Xinjiang Uygur Autonomous Region, China; 2Cardiovascular Hospital, First Affiliated Hospital, 3Department of Biochemistry, Basic Medical College, Xinjiang Medical University, Urumchi 830054, Xinjiang Uygur Autonomous Region, China;Polymorphism of cystathionine-beta-synthetase gene and plasma homocysteine in relation to coronary heart disease in Uygur and Han populations in Xinjiang[J];Journal of Clinical Rehabilitative Tissue Engineering Research;2007-39
10 Li Yimin, Zhang Qingyu. Wang Peixian. Institute of Medical and Pharmaceutical Science, Tianjin 300070);Progress in research on relationship between homocysteine and ischemic arteriosclerosis[J];Chinese Journal of Cardiovascular Medicine;2002-06
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