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《International Medicine & Health Guidance News》 2003-10
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Inquiring relation between methylene tetrahydrofolate reductase (MTHFR) gene polymorphysm andthe Alzheimer desease

Liu xuejun zhanghuiwen Chen ShengqiangGuangzhou Brain hospital  
Objective To study the distribution of methylene tetrahydrofolate reductase(MTHFR) gene in patients with Alzheimer desease , and analyse the relation between them. Method MTHFRgenotyes of patients with Alzheimer desease and age-matched healthy controls were determined by usingthe polymerphism technique,subsequently to require the ratation between MTHFR allele and AD. ResultsMTHFR T allele of patients obviously was higher than cotrols, but MTHFR C allele of patients waslower than cotrols.CONCLUSIONS:The C677T methylenetetrahydrofolate reductase mutation is associatedwith Alzheimer's disease.Conclusion In ApoE allele , ?4 allele is a genetic suscetible factor inADandACI, ?3 allele is a protection factor.
【CateGory Index】: R749.16
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