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《Acta Medicinae Sinica》 1999-06
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The Enhancement of Inhibitory Action of Cisplatin on Human Nasopharyngeal Carcinoma Cell by Coixenolide

Hu Xiaoke 1,LI Yu 2, CHEN Ning 2,LIANG Changsheng 2//1.Department of Nuclear Medicine of Sun yat sen University of Medical Science,Guangzhou (510089) ;2.Guangdong Provincial Institute of Traditional Chinese Medicine,Guangzhou (510095)  
Purpose:To consider the influence of coixenolide (CXL) on antitumour effect of cisplation (DDP) in human nasopharyngeal carcinoma (NPC) cell line CNE 2Z.Method:Microcolony formation assay was used in testing sensitivity of CNE 2Z to DDP.Results:DDP dose dependently inhibited the proliferation of CNE 2Z with ID 50 value of 10 -5.548 ±10 -6.326 mol/L.Addition of CXL (10 -7 and 10 -6 mol/L)shifted the DDP dose effect curve to the left and brought ID 50 down to 10 -5.686 ±10 -6.434 mol/L and 10 -5.874 ±10 -6.686 mol/L respectively.CXL also produced a displacement to the left of the DDP time response curve,which made the action time of DDP be shortened.CXL did not potentiate the DDP cytotoxity to CFU GM in normal bone marrow of mouse.Conclusion:CXL selectively enhances the inhibition of CNE 2Z proliferation by DDP.
【Fund】: 广东省中医药管理局资助!项目(No.97266)
【CateGory Index】: R730.5
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【Citations】
Chinese Journal Full-text Database 2 Hits
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【Co-citations】
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1 SUN Bao-sheng~1,LIU Xiao-lan~2,LIU Lin-lin~3,FU Shi-bo~1,WU Zhen-feng~2,GONG Shou-liang~(1*)(1.MH Radiobiology Research Unit,School of Public Health,Jilin University,Changchun 130021,China;2.Department of Radiotherapy,Fourth Hospital,Chinese Medical University,Shenyang 110032,China;3.Department of Radiotherapy,Second Hospital,Jilin University,Changchun 130021,China);Suppressive effects of ginsenoside Rg3 combined with X-ray irradiation on growth of melanoma cells[J];Journal of Jilin University(Medicine Edition);2006-06
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3 LI Yu, WU Di hua,HU Xiao ke//Guangdong Provincial Institute of Traditional Chinese Medicine, Guangzhou 510095, China;The Inhibitory Action of Coixenolide on Metastasis in Nude Mice Bearing Human Nasopharyngeal Carcinoma[J];Acta Medicinae Sinica;2003-01
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6 Li Yu1,Hu Xiaoke2,Hu Zuguang1,Wu Dihua1,Xiong Daishui1//Guangdong Provincial Institute of Traditional Chinese Medicine1,Guangzhou (510095);Sun Yatsen University of Medical Science2,;Inhibitory Effect of Coixenolide on the in Vitro Growth of Human Nasopharyngeal Carcinoma CNE2Z Cells[J];ACTA MEDICINAE SINICA;1999-03
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