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《Acta Medicinae Sinica》 2015-02
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The value of dynamic changes of serum CA125 level on the efficacy of cytoreductive surgery after neoadjuvant chemotherapy in patients with epithelial ovarian cancer

MA Yu-yi;LUO Ye-lin;GUO Zi-yun;Department of Obstetrics and Gynecology,Wuzhou Red Cross Hospital;  
Objective:To investigate the significance of dynamic changes of serum CA125 level on the efficacy of cytoreductive surgery after neoadjuvant chemotherapy(NACT)in patients with epithelial ovarian cancer.Methods:Blood samples from 40 patients with epithelial ovarian cancer treated by cytoreductive surgery after NACT were collected,and the serum CA125 levels were quantitatively determined by chemiluminescence immunoassay(CLIA)before the treatment,3weeks after each course of chemotherapy,and 7to 14 days before and after the surgery.The dynamic changes of CA125 parameters including half-life,declining rate after the first cycle of chemotherapy,and the effect of cytoreductive surgery after NACT were analyzed.Results:The CA125half-life were decreased significantly in patients who received completely or partial remmison(CR/PR)after NACT or with satisfactory effect of cytoreductive surgery after NACT(residual lesion1cm)than those with tumors stability or without satisfactory effect(residual lesion ≥ 1cm)respectively((P 0.05).However,the CA125 declining rate after the first cycle of chemotherapy was significantly higher in the former groups than that in the latter group(P 0.05).Conclusion:It is suggested that the serum CA125half-life and its declining rate after the first cycle of NACT will be helpful to appraise the effect of NACT and cytoreductive surgery for epithelial ovarian cancer.
【Fund】: 广西梧州市科学研究与技术开发计划资助项目(200701018)
【CateGory Index】: R737.31
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