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Clinical Analysis of Advanced Nasopharyngeal Carcinoma Treated With a Combination of Irradiation and Coix Seed

Li Yu//Guangdong Institute of Traditional Chinese Midicine,Guangzhou 510095  
Eighteen cases of locally advanced (stages Ⅲ and Ⅳ) nasopharyngeal carcinoma (NPC) received radiotherapy combined with coix seed (long term administration).The primary and metastatic carcinomas in cervical lymph nodes disappeared completely 3 months after radiation in 17 and 16 patients respectively.The residual tumor in nasopharynx was found in one case,with10mm in diameter.The remnants in cervical lymph nodes were observed in 2 patients,each diameter was less than 10mm.2 patients suffered from recurrent primary NPC and 2 cases developed distant bone metastasis one year after irradiation.Among them,2 patients died of these events,one had no evidence of disease following reradiation to the recurrent tumor,one was still alive with metastasis.15 patients were free of disease with a minimum followup of 3 years.The results suggested that coix seed might increase susceptibility of NPC to radiation and inhibited its growth and metastasis. In addition,coix seed could improve cellular immune status that played an important role in preventing NPC from recurrence and metastasis.Otherwise,radiationrelated sequelae were not reduced.
【CateGory Index】: R739.63
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