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《ACTA MEDICINAE SINICA》 1999-03
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Inhibitory Effect of Coixenolide on the in Vitro Growth of Human Nasopharyngeal Carcinoma CNE2Z Cells

Li Yu1,Hu Xiaoke2,Hu Zuguang1,Wu Dihua1,Xiong Daishui1//Guangdong Provincial Institute of Traditional Chinese Medicine1,Guangzhou (510095);Sun Yatsen University of Medical Science2,  
The antitumor effect of coixenolide (CXL) was studied with human nasopharyngeal carcinoma CNE2Z in vitro by MTT assay.CXL was found to suppress the proliferation of CNE2Z in a dosedependent manner,with an ID50 of 10-4.95mol/L.The relative potency of CXL was 18.6% of cisplatin (DDP) as compared by their ID50s.The timeresponse curve showed that the inhibitory effect of CXL was observed 12h after its addition and the effect increased with time,and become stablized after 36h. CXL also prolonged the duplication time (TD) of CNE2Z by 40.0%.No cytotoxicity on normal bone marrow was observed.The experiment result indicates that CXL selectively inhibits the growth of CNEZ probably by reducing proliferative ability of the tumor cells.
【Fund】: 广东省自然科学基金
【CateGory Index】: R739.63
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