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《The Chinese Journal of Clinical Pharmacology》 1988-01
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IMMUNE MODULATING EFFECT OF OLEANOLIC ACID

SUN Yan;YUAN Rui-Rong;WU Nai-Ju;LI Wei-Min;HU Qing-Long;QIU Yue;ZHAO Tai Cancer Hospital Chinese Academy of Medical Sciences, Beijing Tianjin Institute of Medicine and Materia Medica, Tianjin  
The results of in vitro and in vivo experimental studies show that Oleanolic acid isolated from Ligustrum lucidum is effective inthe enhancement of stimulation of lymphocyte proliferation, phagocytosisof macrophages, and abrogation of excess Ts activity in cancer patientsand also induced by ConA in vitro study. There is also evidence that theimmune modulating effect of Oleanolic acid is synergistic with the activityof IL-2. Preliminary clinical results reveal that Oleanolic acid was ableto improve both the function of lymphocytes and macrophages in cancerpatients, and confirm that Oleanolic acid is one of the active componentsof Ligustrum lucidum in immune modulation. No change was observed ina group of patients who received placebo. Further experimental study andclinical trials are suggested.
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