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《The Chinese Journal of Clinical Pharmacology》 2003-06
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Relative bioavailability and bioequivalance of troxipide capsule in healthy volunteers after a single oral administration

ZHAO Ya-nan, QIU Fu-rong, WANG Wei-jia, SUN Hua, DAI Min, YANG Qing-qing, MAO Guo-guang (National Drug Clinical Research Base, Yijishan Hospital, Wannan Medical College, Wuhu 241001, China)  
Objective To study the pharmacokinetics and relative bioavailability of troxipide capsule. Methods A single oral dose of 100 mg troxipide capsule (test group) and tablet (control group) were given to 18 healthy volunteers in an open randomized crossover design. The concentrations in plasma were determined by reverse phase HPLC method. Results The main pharmacokinetic parameters were as follow: t1/2ke were 6.52 ± 1.62 and 7.03 ± 2.27 h, tmax were 2.89 ± 0.93 and 2.97 ± 1.25 h, Cmax were 0.98 ± 0.27 and 1.06 ±0.31 mg.L-1, AUC0-24 were 15.18 ± 4.11 and 15.96± 3.97 mg.h.L-1, AUC0- were 15.83 ± 4.12 and 16.82 ± 4.47 mg .h .L-1 for test and control, respectively. Conclusion The results of statistics analysis demonstrated that two formulations were bioequivalent.
【CateGory Index】: R96
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 LIANG Mao-zhi,YU Qin and ZOU Yuan-gao (Institute of Clinical Pharmaocology,West China University of Medical Sciences,Chengdu 610041);RP-HPLC Determination of Troxipide in Human Serum[J];Chinese Journal of Pharmaceutical Analysis;2001-01
【Co-citations】
Chinese Journal Full-text Database 1 Hits
1 SHI Zhixian, LIU Mei, YANG Yueqin and H U Fengzu(Northwest Plateau Institute of Biology, the Chinese Academy of Scienc es,Xining,810001);Advances in high performance liquid chromatography and related techniques of 200 1~2002 in China[J];Analytical Laboratory;2003-05
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 ZHOU Shi-wen, TANG Jian-lin, XU Ying, HUANG Yong-ping, YING Yi (Base for Drug Clinical Trial, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China);Experimental evaluation of the bioequivalence of irbesartan capsules[J];Acta Academiae Medicinae Militaris Tertiae;2004-22
2 DAI Kai-jin 1 , LUO Qi-zhi 2 , LUO Jia-bo 1 , MA An-de 2 1 Key Laboratory of New Drug Development in Traditional Chinese Medicine, 2 Central Laboratory, First Military Medi-cal University, Guangzhou 510515, China;High-performance capillary electrophoresis for determining the contents of berberine,jatror-rhizine and palmatine in Gegenqinlian decoction[J];Journal of First Military Medical University;2003-07
3 DAI Kai-jin 1 , LUO Qi-zhi 2 , LUO Jia-bo 3 , TAN Xiao-mei 3 , MA An-de 2 1 Department of Chemistry, 2 Center Laboratory, 3 Key Research Laboratory of New Traditional Chinese Drugs, First Military Medical University, Guangzhou 510515, China;Determination of the total alkaloid content of Rhizoma coptidis in Gegenqinlian prescription[J];Journal of First Military Medical University;2004-04
4 YU Lin-Zhong, WU Jie-yong, LUO Jia-Bo, CHEN Yu-rao, LIN Hui Department of Traditional Chinese Medicine Pharmacology, Faculty of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China;Effects of different compositions of Gegenqinlian decoction on experimental shigellosis in rabbits[J];Journal of First Military Medical University;2005-09
5 LIU Let LI Ke-Xin U Yans HE Guang-Wei SUN CHun-Hua (Clinical Pharmacology Base, Beijing Hospital,Beijing 100730);Bioequivalence of Isosorbide-5-monomirate Sustained Release Capsule in Healthy Volunteers by HPLCIMS[J];The Chinese Journal of Clinical Pharmacology;2001-03
6 YAO CHen1 CHEN Feng2 ZHANGGao-Kui1 LIU Yu-Xiu3 CHENG Qi-Guang4 SU Bing-Hua5 1(Department of Medical Statistics,General Hospital of PLA, Beijing 100853) 2(Department of Medical Statistics, Nantong Medical College, Nantong 226001) 3(General Hospital of Nan;Equivalence Test for Cross-over Clinical Trial[J];The Chinese Journal of Clinical Pharmacology;2001-04
7 LIUYu-Xiu YAO Chen CHEN Feng CHEN Qi-Guang SUBing-Hua SUN Rui-Yuan(General Hospital of Nanjing Command PLA, Nanjing 210002)(Department of Medical Statistics, General Hospital of PLA, Benjing 100853) (Department of Medical Statistics, Nantong Medical College, Nantong 226001) (Department of Epidemiology and Biostatistics, Southeast University, Nanjing 210009) (Department of Biostatistics, Shanghai Second University of Medical Sciences, Shanghai 200025)(Institute of Clinical Pharmacology, Wannan Medical College, Wuhu 241001);Equivalence Analysis for Multiple Cross-over Design of Bioavailability Trials[J];The Chinese Journal of Clinical Pharmacology;2002-03
8 ZHANG Xue-Zhong, MA Lin-Mao (Chinese Academy of Preventive Medicine, Beijing, 100050);STATISTICAL DESIGN AND ANALYSIS OF BIOEQUIVALENCE STUDIES BY EXAMPLE[J];THE CHINESE JOURNAL OF CLINICAL PHARMACOLOGY;1999-03
9 ZHOU Yuan QIU Hua * LIU Min (Chemistry and Life Science College,Three Gorges University,Yichang,Hubei 443003,P.R.China) *(Yichang Minkang Pharmaceutical Co.,Ltd.,Yichang,Hubei 443003,P.R.China);Determination of the Trace Elements in Pueraia Flavonid Produced at Yichang[J];Chinese Journal of Spectroscopy Laboratory;2003-06
10 ;Disscussion on Superfine Comminution of Chinese Herbs[J];Hunan Guiding Journal of Traditional Chinese Medicine and Pharmacology;2004-10
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