Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《The Chinese Journal of Clinical Pharmacology》 2004-06
Add to Favorite Get Latest Update

Safety and tolerance of torasemide after a single and multiple oral administration

JIANG Wen, LI Yi-shi, HUA Lu,HUANG Yan, LIU Han, SU Qi,WANG Bei, CHENG Xiao-ru, ZHANG Yin-feng(Department of Clinical Phar-macology,Cardiovascular Instituteand Fuwai Hospital, ChineseAcademy of Medical Sciences andPeking Union Medical College,Beijing 100037, China)  
Objective To evaluate the diuretic effect and safety of different andmultiple doses torasemide. Methods Nineteen normal male healthy subjects receivedsingle dose of either 5, 10 or 20 mg po with one week interval or single dose of 10 mgpo every morning for 7 days. Urine and volume of intake over 24 h period, bloodpressure, respiratory and heart rates, 24 h urine potassium/ sodium/chloride/creatinine/ calcium, complete blood count and chemistry, urinalysis andelertrocardiogram before and after the administration. Results Twenty-four h urinevolume after taking torasemide 5,10,20 mg were 2.14,2.60,3.17 L, respectively(P0.05). There are a little increase with three doses about the urine potassium, sodium,chloride excretion over 24 h period. Urine volume and urine potassium, sodium,chloride excretion over 24 h period were highest after the first administration. Nodecrease in serum potassium, sodium, chloride after single dose and multiple doseswhile triglyceride increased 0.1~0.4 mmol.L-1. Four volunteers had adverse effects.Conclusion There was a clear dose-response relationship for diuretic activity. Goodtolerance and safety profile were observed in the given doses.
【CateGory Index】: R96
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 3 Hits
1 JIA Zaishen, HOU Xiaotong, LIU Xiaoming, LIU Xiaojun, LI Yanping, SUN Zhiquan, HAN Jingmei, GONG Qingcheng Department of Cardiopulmonary Bypass, Capital Medical University affiliated Beijing Anzhen Hospital, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing 100029, China;The Effects of different diuretics on the electrolytes in cardiac valve replacement surgery with cardiopulmonary bypass[J];Journal of Cardiovascular and Pulmonary Diseases;2009-03
2 ZHENG Wen-yan,CAO Yu-ping Nanjing Hicin Pharmacertical Co.Ltd,Nanjing 210019,Jiangsu,China;Clinical randomized controlled trial on torasemide injection in treating patients with congestive heart failure and edema[J];Chinese Journal of Clinical Pharmacology and Therapeutics;2008-06
3 YUAN Chun-mei, MA Liang, YAN Jing;Clinical observation and nursing of Torsemide in Treatment of Patients with Renal Edema[J];Occupation and Health;2009-23
Chinese Journal Full-text Database 9 Hits
1 LI Xue-Ning CHEN Wei-Li XU Hong-Rong HUANG Jin-Pei LI Zhi-SHan (Department of Clinical Pharmacology Zhong Shan Hospital Fudan University,;Study of the Tolerance and Diuretic Properties of Torasemide Following Intravenous Administration to Chinese Healthy Volunteers[J];The Chinese Journal of Clinical Pharmacology;2002-01
2 Xu-Ping Zhou, Shi-Yao Bao Department of Neurology, the Second Affiliated Hospital of Suzhou University, Suzhou 215004, China;Brain Edema After Acute Stroke[J];Cerebrovascular Diseases Foreign Medical Sciences;2005-01
3 YANG Tienan,CHI Yifan,SUN Zhongdong,et al.Dept. of Cardiac Surgery,Qingdao Mucinipal Hospital,Qingdao 266011;Surgical treatment of mechanical valve replacement to the patients with giant rheumatic heart disease[J];Journal of Cardiovascular and Pulmonary Diseases;2004-02
4 LIN Gui-zhen~(1),LIN Guo-sheng~(2),ZHENG Min-an~(1),HAN Bin~(1)()~(1)The third hospital of WuHan(WuHan 430060)()~(2)Wuhan municipal bureau of health(WuHan 430014,China);Observe the Effect of Torasemide Short-term Therapy in Patients with CHF and BNP[J];Jiangsu Pharmaceutical and Clinical Research;2006-01
5 SU Qi 1, LI Yishi 1, CHEN Junzhu 2, et al (1 Department of Clinical Pharmacology, Cardiovascular Institute and Fu Wai Hospital, CAMS and PUMC, Beijing 100037 China 2 Department of Cardiology, First hospital of ZheJiang University, HangZhou ZheJiang 310003 China);Efficacy and Safety of Torasemide in Patients with Mild to Moderate Essential Hypertension[J];Chinese Journal of Hypertension;2003-04
6 MA Hong, CHEN Xiangmei, WANG Jianzhong, et al. (Division of Nephrology, Kidney Center and Key Lab of PLA, General Hospital of PLA, Beijing 100853, China);Change of PAs/PAI-1 system and effect of interfering therapy in 7/8 nephrectomized rats[J];Chinese Journal of Nephrology;2001-04
7 XUE Hen,FAN Jun- ming,CHEN Liang,LI Zi,HU Zhang-xue ,LIU Xian-rong. Department of Nephrology, West China Hosipital, Shichuan University, Chengdu, 610041, China;Identification and characterization of hepatocyte growth factor in counteracting tubular epithelial- myofibroblast transdifferentiation in renal interstitial fibrosis[J];Chinese Journal of Nephrology;2005-08
8 HE Ping WU Wei YANG Kang. ICU,Department of Cardiothoracic Surgery,South-west Hospital,the Third Military Medical University,Chongqing 400038,China;Clinical effect of torasemide on the patients after cardiac valve replacement in ICU[J];Chinese Journal of Critical Care Medicine;2007-11
9 HUA Lu,LI Yi-shi,SONG Zhen (Department of Clinical Pharmacology , Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences , Beijing 100037, China );Torasemide,a new loop diuretics[J];Chinese New Drugs Journal;2003-11
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved