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《The Chinese Journal of Clinical Pharmacology》 2004-06
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Safety and tolerance of torasemide after a single and multiple oral administration

JIANG Wen, LI Yi-shi, HUA Lu,HUANG Yan, LIU Han, SU Qi,WANG Bei, CHENG Xiao-ru, ZHANG Yin-feng(Department of Clinical Phar-macology,Cardiovascular Instituteand Fuwai Hospital, ChineseAcademy of Medical Sciences andPeking Union Medical College,Beijing 100037, China)  
Objective To evaluate the diuretic effect and safety of different andmultiple doses torasemide. Methods Nineteen normal male healthy subjects receivedsingle dose of either 5, 10 or 20 mg po with one week interval or single dose of 10 mgpo every morning for 7 days. Urine and volume of intake over 24 h period, bloodpressure, respiratory and heart rates, 24 h urine potassium/ sodium/chloride/creatinine/ calcium, complete blood count and chemistry, urinalysis andelertrocardiogram before and after the administration. Results Twenty-four h urinevolume after taking torasemide 5,10,20 mg were 2.14,2.60,3.17 L, respectively(P0.05). There are a little increase with three doses about the urine potassium, sodium,chloride excretion over 24 h period. Urine volume and urine potassium, sodium,chloride excretion over 24 h period were highest after the first administration. Nodecrease in serum potassium, sodium, chloride after single dose and multiple doseswhile triglyceride increased 0.1~0.4 mmol.L-1. Four volunteers had adverse effects.Conclusion There was a clear dose-response relationship for diuretic activity. Goodtolerance and safety profile were observed in the given doses.
【CateGory Index】: R96
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