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《The Chinese Journal of Clinical Pharmacology》 2008-04
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Infectious diarrhea bacterial pathogens monitoring and resistance to antibiotics in Beijing

HOU Feng-qin1,WANG Yong2,SUN Xin-ting1,WANG Gui-qiang1 (1.Infectious Department of Peking University First Hospital, Beijing 100034,China;2.Diseases Prevention and Control Office of Academy Military Medical Sciences,Beijing 100071,China)  
Objective To investigate the distribution, the resistance of bacterial pathogens isolated from acute diarrheal patients in Beijing. Methods Enteric pathogenic bacteria were isolated by feces culture. Antimicrobial susceptibility were carried out in Kirby-bauer method.Results Shigella spp.(23.4%) was still the most frequently detected pathogen in all of the pathogens resulted in diarrhea. The rate of conditional pathogenic bacteria such as Bacterium termo, Enterococci, and so on increased to 32.4%. The rate of resistence of bacterial pathogens often caused diarrhea to both ampicllin and trimethoprim-sulfamethoxazole were within 40%~100%, while to fluoroquinolones were less than 15%(excepted for Saimonella 20%), and to the third generation of cephalosporins were about 10%.Conclusion The rate of conditional pathogenic bacteria increased,which should be taken seriously . The rates of resistence of all pathogens caused diarrhea to fluoroquinolones were less than 20%, so can be remained as first-line medicines for infectious diarrhea.
【Fund】: 国家863基金资助项目(2006AA020703);; 北京市科委基金资助项目(D0206010041091)
【CateGory Index】: R446.5
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【References】
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