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《The Chinese Journal of Clinical Pharmacology》 2016-15
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Expression and clinical significance of serum Chemerin in patients with ischemic stroke

LAN Wei-ming;MA Le-le;Department of Cardiac and Cerebral Vascular,People's Hospital of Jingning Shezu Autonomous County,Lishui;  
Objective To evaluate the clinical significance of serum Chemerin expression in patients with ischemic stroke( AIS). Methods Fifty eight cases of ischemic stroke were recruited from May 2013 to April2015 in our hospital and were divided into treatment group( n = 27) and control group( n = 31) according to the results of digital subtraction angiography( DAS). The serum levels of Chemerin were detected by double antibody sandwich enzyme- linked immunosorbent assay,and were compared between the two groups. The sensitivity and specificity of Chemerin to the cerebral artery stenosis in AIS patients as well as its correlation with C- reaction protein( CRP) were evaluated according to the serum level of Chemerin. Results The serum levels of Chemerin were( 102. 10 ± 19. 50) ng · m L~(-1)and( 81. 90 ± 17. 60) ng · m L~(-1)in treatment group and control group respectively with statistical difference( P 0. 001). The serum levels of CRP were( 9. 50 ± 2. 10) mg·m L~(-1)and( 8. 40 ± 1. 90) mg · m L in treatment group and control group respectively with statistical difference( P 0. 05). The serum level of low density lipoprotein- cholesterol in treatment group was( 3. 87 ± 0. 88)mmol·L~(-1)which was significant higher than that of control group with( 3. 01 ± 0. 67) mmol·L~(-1)( P 0. 001). The determined sensitivity and specificity were 76. 60% and 70. 30% with the area under the roc( AUC) of 0. 78 according to the serum Chemerin level. Significant positive correlation was found between serum Chemerin and CRP( P 0. 001)Conclusion Significant correlation between serum Chemerin and CRP was found in patients with ischemic stroke. And the serum Chemerin can be used as an indirect indicator to diagnose the cerebral artery stenosis.
【Fund】: 丽水市社会发展基金资助项目(2014SH007)
【CateGory Index】: R743.3
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