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A study of anticoagulant properties on carboxylated graphene oxide-La composite

WANG Xiao-dan1,2,ZHOU Ning-lin1,2,3,WANG Wei-yan1,2,TANG Yi-da1,2,ZHANG Jun1,2,3,MO Hong1,2,3,SHEN jian1,2,3 (1.Jangsu Engineering Research Center for Biomedical Functional Materials,Nanjing Normal University,Nanjing 210097,China; 2.Jiangsu Key Laboratory of Biofunctional Materials,College of Chemistry and Environmental Science,Nanjing Normal University,Nanjing 210097,China; 3.Jiangsu Technological Research Center for Interfacial Chemistry and Chemical Engineering,Nanjing University,Nanjing 210093,China)  
In this paper,a functional graphene oxide was prepared with La3+ ions and the carboxylated graphene oxide sheet.The structure and properties of GeneO-La composite was characterized by Fourier transformed infrared specttroscopy(FT-IR) and trans mission electron microscopy(TEM);the functional graphene oxide was added to anticoagulation system and its effects on anticoagulant properties were studied.Results show that the La3+ ions have been coordinated on graphene oxide sheet layer.The blood compatibility of the GeneO-La composite was evaluated by plasma recalcification time test and hemolysis test.It was observed that the plasma recalcification time gradually shortened with the increase in the concentration of composite,and hemolysis rate were less than 5% in lower concentrations,it conformed to the hormesis effect of rare earth elements.Therefore,the GeneO-La composite is a new carboxylated graphene oxide composite,which has anticoagulant effect when it has lower concentrations.
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