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《Journal of Functional Polymers》 2001-01
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Preparation of Porous cell Scaffolds of Poly(L-lactic acid) and Poly(L-lactic-co-glycolic acid) and the Measurement of their Porosities

SHI Gui xin, WANG Shen guo, BEI Jian zhong (Center for Molecular Sciences , Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China)  
The highly porous biodegradable cell scaffolds of poly(L lactic acid) and poly(L lactic co glycolic acid) were prepared with a solution casting and porogen particular leaching technology. An improved method in which a density bottle was used instead of a graduated cylinder to measure the porosity of the porous scaffold. It was found that the porosity of the porous scaffold increased with the porogen weight fraction , independent of porogen particle size. As the content of the glycolic acid in poly(L lactic glycolic acid) copolymer increased, the porosity of the porous PLGA scaffold decreased. The median pore diameter depended on the size of porogen particle. It was also found that the cartilage proliferated in the poly(L lactic co glycolic acid) scaffold and secreted extracellular matrix(ECM).
【Fund】: 国家重点基础研究发展规划项目! (G19990 5 43 0 6)
【CateGory Index】: O631
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