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《Journal of Functional Polymers》 2018-02
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Fabrication and Properties of Suncream Nanocapsules Loaded with Octocrylene

LIU Tian-qun;ZHAO Di;LI Xue-ting;KANG Yuan-yuan;SHI Xiao-di;LU Xi-hua;College of Chemistry,Chemical Engineering and Biotechnology,Donghua University;  
Suncream nanocapsules(NCs)loaded with Octocrylene(OCT)and caprylic/capric triglyceride(GTCC)were prepared by interfacial free-radical polymerization using ethylene glycol dimethacrylate(EGDMA)as monomer and ammonium persulfate(APS)as initiator.Morphology,core-shell structure,particle size distribution and chemical components of NCs were characterized by Scanning Electron Microscope(SEM),Transmission Electron Microscope(TEM),particle size Zeta potential(Nano-ZS)analyzer and Fourier Transform Infrared(FT-IR)spectroscopy,respectively.And the Cell Counting Kit-8(CCK-8)assays were used to investigate the biocompatibility of suncream NCs.Besides,the prepared suncream NCs were added in reference cream to test its sun protect factor(SPF)by UV transmittance analyzer.Results of SEM showed that when the mass fraction of GTCC was 10%in the core materials,the NCs possessed spherical morphology.The analysis of FI-TR and the presence of core-shell structure illustrated that the core materials were encapsulated.And the average particle size of the optimized NCs was about 318 nm with a narrow polymer dispersity index(PDI=0.293).Compared to the cream with the non-encapsulated OCT/GTCC,the cream containing suncream NCs showed obviously higher SPF.Moreover,the result of CCK-8 indicated that the NCs could decrease the toxicity of OCT and possessed good biocompatibility.
【Fund】: 国家自然科学基金(51473032 51503034)
【CateGory Index】: TB383.1;TQ658.24
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