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《Journal of Gannan Medical College》 2002-01
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The Anti-arrhythmia Effect of Epimedium Breuicornum Maxin(EBM)

ZENG Jing,HUANG Yu shan,HUANG Xian hua,et al (Department of Pharmacology,Gannan Medical College,Ganzhou,341000)  
Objective:To study the anti arrhythmia effect of Epimedium Breuicornum Maxin(EBM).Methods:The conventional anti arrhythmic methods were used.Results:It had been found that EBM was markedly effective in preventing ventricular fibrillation induced by chloroform in mice and induced by calcium chloride.EBM can markedly inhibit the arrhythmia induced by aconitine in rats.But EBM cannot antagonize the arrhythmia induced by adrenaline in rabbits.And EBM can obviously inhibit the action potential amplitude of isolated sciatic nerves in toads.Conclusion:EBM has obviously protective effect on drugs induced arrhythmia,which may be related to its inhibition of Na + or Ca 2+ influx.
【Key Words】: Epimedium Breuicornum Maxin arrhythmia
【CateGory Index】: R285.5
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