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The Inhibitory Effects of Osthol on Central Nervous System

Zhou Qing,et al  
Osthol (Ost)markedly potentiated the hypnotic effect induced by a low hypnotic threshold dose of pentobarbital mice writhing induced by the hot plate.Osthol antagonised the excitable activity induced by caffeine,but it did not influence the autonomic activity in mice of control group.Furthermore,osthol decreased the action potential amplitude of isolated sciatic nerves in toads.These results indicated that osthol had the inhibitory effects on central nervous system.
【CateGory Index】: R285.5
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