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《Chinese Journal of Infection Control》 2008-01
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Analysis on drug-resistance of Staphylococcus aureus causing infection in children

DENG Qiu-lian1,DENG Li1,XIE Yong-qiang1,HUANG Yong1,ZHONG Hua-min1,YANG Yong-hong2(1.Guangzhou Children's Hospital,Guangzhou 510120,China;2.Beijing Children's Hospital,Beijing 100000,China)  
Objective To realize the drug-resistance of Staphylococcus aureus in infected children and clindamycin resistance induced by erythromycin.Methods Staphylococcus aureus were collected from patients who were hospitalized between January 2005 and December 2007,2 086 strains were isolated from children with impetigo herpetiformis in department of dermatology and 158 strains were from children without impetigo herpetiformis in the other departments,analysis was made on antimicrobial susceptibility tests of the above strains against 13 kinds of antimicrobial agents performed with Kirby-Bauer methods,drug-resistant phenotype of clindamycin induced by erythromycin was detected by D-test.Results The drug-resistant rates of 2 086 strains of Staphylococcus aureus causing impetigo herpetiformis to penicillin,erythromycin and clindamycin were high,which were 96.2%,83.2% and 61.9% respectively,but drug-resistant rates to the other antimicrobial agents were low(0~6.2%);27 strains(1.29%)were methicillin-resistant Staphylococcus aureus(MRSA).The drug-resistant rates of Staphylococcus aureus causing non-impetigo herpetiformis infection against penicillin,erythromycin and clindamycin were 97.5%,56.9% and 32.9% respectively,drug-resistant rates to cephalosporins were 14.6%~27.3%,drug-resistant rates against the other antimicrobial agents were all5%;28 strains(17.72%)were MRSA,432 strains were erythromycin-resistant but clindamycin-sensitive,232 strains were positive in inducible test,53.70% strains were clindamycin-resistant strains induced by erythromycin.Conclusion The detection rate of MRSA was low in children with impetigo herpetiformis but high in non-impetigo herpetiformis infection,both were highly resistant to penicillins,macrolides and lincosamides,but the resistant rates to the other antimicrobial agents were low.The detection of D-test to determine the phenotype of lincomycin induced by erythromycin can help clinicians to use macrolides,lincosamides and streptogramin correctly.
【Fund】: 国家科技部十五攻关计划项目(2004BA720A09-01);; 广东省科技厅项目(2005B36001022)
【CateGory Index】: R446.5
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