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《Chinese Journal of Infection Control》 2014-10
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Community-acquired infections and risk factors in patients with diabetes:A Meta-analysis

ZHAO Guang-dan;ZHAO Ming-jing;LI Fang-zhi;WANG Ling-ling;SUN Jia-ying;CHEN Dong-hong;WANG Xiao-ge;The Fourth Hospital Affiliated to China Medical University;  
Objective To analyze the types and risk factors of community-acquired infections(CAI)in diabetic patients by system analysis method of evidence-based medicine.Methods China National Knowledge Infrastructure(CNKI),Wanfang database,VIP database were searched by computer,domestic published researches on CAI and related risk factors in diabetic patients were aggregated,Meta-analysis was conducted by stata 11.0software.Results A total of 12 literatures were included in the study.The average rate of CAI in diabetic patients was 39.55%(22.12%-55.86%).The major infections were respiratory system infection(40.74%),urinary tract infection(27.35%),tuberculosis(10.80%),skin and soft tissue infection(9.19%),and hepatobiliary system infection(5.57%).Stratified analysis on risk factors revealed that OR and OR95%CIof chronic complication,age,disease course,glycemic control,gender,type of diabetes,subtype of ketoacidosis was 1.63(1.45,1.82),1.30(1.19,1.42),1.47(1.35,1.61),0.68(0.61,0.76),0.69(0.64,0.75),1.37(1.13,1.66)and 0.87(0.62,1.23),respectively.There was no publication bias and combined results were stable.Conclusion The main CAI in diabetic patients are respiratory system infection,urinary tract infection,tuberculosis,skin and soft tissue infection,and so on;several factors,such as female,older age,long-term disease course,poor glycemic control,and complication,can contribute to the increase of CAI in diabetic patients.
【Fund】: 国家十一五科技支撑项目(2007BAI24B004);; 辽宁省科技厅项目(20132253030);; 沈阳市科技局项目(F12-277-1-71)
【CateGory Index】: R587.1
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