Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《JOURNAL OF GANSU SCIENCES》 1999-02
Add to Favorite Get Latest Update

THE EFFECT OF TGF β 1 AND bFGF IN THE COLLAGEN DEPOSITION OF ALVEOLAR SEPTUM

Sun Shaohua\ \ Zhu Renzhi\ \ Yang Guorong (Lanzhou Medical College,Lanzhou\ 730000 China)  
The objective is to study the action of transfor ming growth factor β 1 (TGF β 1 )and basic fibroblast growth factor( bFGF)in the collagen deposition of fibrotic interstitial lung desease(FILD)by us ing the methods of HE staining and Masson's trichrome staining and the inmmunohi stochemical SP method.Collagen was singularly deposited in alveolar septum when FILD developed into the late stage.Abnormal collagen deposition in alveolar sept um has four grades.It was demonstrated that the positive rates of TGF β 1 expressed both in pulmonary macrophages and hyperplasia pneumocytes type Ⅱ o f FILD cases were higher than those of diseas control cases,and there was a sign ificant difference between the two groups( P 0.05).However,only the positive rates of TGF β 1 expressed in hyperplasia pneumocytes type Ⅱ of collag en deposited cases were higher than those of no collagen deposited cases( P =0.01),both of which were FILD.The positive rates o bFGF expressed in pulmonary macrophages of FILD cases were higher than those of disease control cases( P 0.025).So the conclusion is that bFGF could cooperate with TGF β 1 . The two cell factors could play a part in the process of abnormal collagen depos ition in FILD.
【CateGory Index】: R563.9
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 2 Hits
1 YANG Guo-rong1, ZHU Ren-zhi2, HE Xiao-xia3, XUE Yong-jie1, HE Xue-jiao1, YU Rong1(1 Department of Pathology, The First Hospital of PLA, Lanzhou 730030, China; 2 The Institute of Pathology, Lanzhou University, 3 Department of Neurosurgery, People's Hospital of Gansu Province, Lanzhou 730000, China. );Expression features of human decorin in E.coli DH5α[J];中国病理生理杂志;2007-06
2 YANG Guo-rong,ZHU Ren-zhi,HE Xiao-xia,et al.(Department of Pathology,The First Hospital of PLA,Lanzhou 730030,China);Preparation of decorin cDNA probe and initial detection of decorin mRNA in tissues[J];西北国防医学杂志;2006-05
【Citations】
Chinese Journal Full-text Database 1 Hits
1 He Bing;ZhaoGuhrong;Liu xin-min, et al. (The Hirst Teaching Hospi-tal, Beijing Medical University 100034);The effect of IL-1 receptor antagonist onbleomycin-induced Pulmonary fibrosis[J];中华结核和呼吸杂志;1994-01
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 SONG Jian-ping1,XIE Zhong-li1,YANG Mei-feng2,LI Wei1,LI Rui-qin1,ZHANG Rui1(1.Henan College of Chinese Medicne,Zhengzhou,Henan 450000; 2.Henan province Puyang city Hospital of Chinese Medicne,Puyang 457000);Effects of norepinephrine,dopamine,5-HT in the lung and brain of rats with pulmonary fibrosis stage by Guifu Dihuang Pill[J];中国中医基础医学杂志;2012-09
2 SONG Jianping 1,XIE Zhongli 1,LI Wei 1,LI Ruiqin 1,ZHANG Rui 2,YANG Meifeng 3(1.College of Preclinical Medicine,Henan University of Chinese Medicine,Zhengzhou 450008;2.Dean's Office,Henan University of Chinese Medicine;3.Puyang Municipal TCM Hospital,Henan Prvoince);Influence of Dahuang Zhechong Pills on Neurotransmitter in the Lung and Brain Tissues in the Formation Stage of Pulmonary Fibrosis of Rats[J];中医杂志;2011-19
3 SONG Jian-ping,XIE Zhong-li*,LI Wei,LI Rui-qin,ZHANG Rui,YANG Mei-feng(Henan College of Chinese Medicine,Zhengzhou 450008,China);Intervention of Gualou Xiebai Decoction on Pulmonary Fibrosis Formation Stage[J];中国实验方剂学杂志;2011-10
4 Li Wei, Li Ruiqin, Song Jianping, Zhang Rui, Zhang Limin (Henan University of Traditional Chinese Medicine, Zhengzhou 450008, China);The Effect of Guifudihuang PiU (GFDH) on Interleukin-10 (TL-10) Expression in Lungs from Bleomycin A5-induced Pulmonary Fibrosis in Rats[J];世界科学技术(中医药现代化);2009-05
5 LI Rui-qin, ZHANG Rui, SONG Jian-ping, LI Wei, TIAN Li(Department of Pathology, Henan University of Traditional Chinese Medicine, Zhengzhou 450000, China);Effect of Gualouxiebai-Soup(GLXBS) on the Initial Stage of Pulmonary Fibrosis induced by Bleomycin A5 in Rats[J];中国医药指南;2009-15
6 LI Rui-qin,SONG Jian-ping,LI Wei,ZHANG Rui,YANG Mei-feng,ZHANG Xian-wei(Henan Chinese Medicine College,Zhengzhou Henan 450003);Impact of Guifudihuang(GFDH) Pill on Expression of Tumor Necrosis Factor-α(TNF-α)of Lung Tissue in Pulmonary Fibrosis Modeling[J];世界中西医结合杂志;2009-06
7 Li Ruiqin, Song Jianping, Zhang Rui, Li Wei (Henan University of Traditional Chinese Medicine,Zhengzhou 450008);Effect of Gualouxiebai Soup(GLXBS) on the initial stage of pulmonary fibrosis induced by bleomycin A5 in rats[J];中药药理与临床;2009-03
8 LI Rui-qin1,XIAO Hong2,ZHANG Rui1,LI Wei1,SONG Jian-ping(1.Henan University of Traditional Chinese Medicine,Zhengzhou 450008,China;2.Henan Workers College of Medicine,Zhengzhou 450008,China);Effect of Gualou Xiebai (GLXB) decoction on platelet-derived growth factor BB (PDGF-BB) expression in lungs from bleomycin A5 induced pulmonary fibrosis in rats[J];中国中药杂志;2008-22
9 SONG Jian-ping~1, LIU Fang-zhou~2, Li Wei~1, LI Rui-qin~1, Zhang Rui~1(1.Henan College of TCM,Zhengzhou, 450083,China;2.Henan Institute of TCM,Zhengzhou 450006,China);Effect of Jingui Shenqi Pill on TNF-α expression in lungs from bleomycin A5-(induced) pulmonary fibrosis in rats[J];中成药;2006-01
10 Song Jianping, Tian Li, Li Ruiqin, Zhang Rui(Henan College of Traditional Chinese Medicine, Zhengzhou, Henan, 450008);Influence of Gualou Xiebai Decoction on Lung Tissues and SOD Vatality in Blood Serum of Rats with Pulmonary Fibrosis[J];河南中医;2005-08
【Co-references】
Chinese Journal Full-text Database 4 Hits
1 YANG Guo-rong,ZHU Ren-zhi,HE Xiao-xia,et al.(Department of Pathology,The First Hospital of PLA,730030,China);Molecular clone of Decorin cDNA and its expression in E.coli DH5α[J];西北国防医学杂志;2005-05
2 SHI Wei~1, HE Chao-sheng~1, LIU Shuang-xin~1, LIANG Xin-ling~1, YE Zhi-ming~1, LIANG Yong-zheng~2, HU Xiang-ming~1, WANG Zhao-jie~2 (~1Department of Nephrology,?~2?Department of Pathology, Guangdong Provincial People's Hospital, Guangzhou 510080, China);Role of TGF-β_1 and its signaling transduction molecule Smad4 in the development of glomerulosclerosis[J];中国病理生理杂志;2005-07
3 Sun Shaohua, Yang Guorong, Sun Xiaowei et al (Dept of Pathol, Lanzhou Medical College, Lanzhou 730000);The role of pulmonary macrophages in fibrotic interstitial lung disease of human[J];临床与实验病理学杂志;1999-05
4 Sun Shaohua\ \ Zhu Renzhi\ \ Yang Guorong (Lanzhou Medical College,Lanzhou\ 730000 China);THE EFFECT OF TGF β 1 AND bFGF IN THE COLLAGEN DEPOSITION OF ALVEOLAR SEPTUM[J];甘肃科学学报;1999-02
【Secondary References】
Chinese Journal Full-text Database 3 Hits
1 XING Bang-rong;CHEN Yu-xian;ZENG Hua;YANG Xiao-yan;LIANG Cai-qian;ZHOU Wei-xiong;KONG Qing-lei;HAN Jian-hua;ZHANG Yong-biao;Department of Emergency,The Third Affiliated Hospital of Sun Yat-sen University;Department of Orthopaedics,The Third Affiliated Hospital of Sun Yat-sen University;;Effect of decorin on proliferation and collagen type I synthesis of stiff knee joint synovial type B cells[J];中国病理生理杂志;2015-07
2 GUO Xiao-li(College of Life Science,Hengshui University,Hengshui,Hebei 053000,China);Studies on the Growth Appearance of E.coli DH5α[J];衡水学院学报;2010-01
3 YANG Guo-rong, XUE Yong-jie, JIA Xing-min, HE Xiao-xia, HE Xue-jiao, YU Rong Department of Pathology, The First Hospital of PLA, Lanzhou 730030, China;Role of decorin in liver fibrosis[J];肝脏;2007-06
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved