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《Western Journal of Traditional Chinese Medicine》 2015-01
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Meta Analysis of Kaishi Injection in the Treatment of Sudden Deafness

LI Yue;LI Junping;ZHU Yajun;Otorhinolaryngology Department of People′s Hospital of Lintao County;  
Objective: To evaluate the clinical trials and effects of Kaishi injection(alprostadil) in treating sudden deafness. Methods: Database were searched; data was screened and abstracted by two investigators according to the standard of inclusion and exclusion,the quality of included literature was assessed by quality assessment of randomized controlled trial from Cochrane net and Meta analysis was performed by Rev Man 5.2 software. Result: Six pieces of writing were included. The results of Meta analysis showed: Treatment group was superior to the control group in clinical effects [OR=2.31,95% CI(1.45,3.02)],the differences between the two groups had statistical signficance. Conclusion: Although Kaishi injection can treat sudden deafness effectively, it is restrictive in the accurate curative effect for inadequate sample sizes and lower sample qualities. Therefore it is essential to do the randomized controlled clinical trials with multicenter and adequate samples to supply the objective basis for the treatment of sudden deafness by using Kaishi injection.
【CateGory Index】: R764.437
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 XU Qingqing,LI Yaorong(Guangdong Foshan No.1People’s Hospital,Foshan528000,China);Treating Sudden Deafness with Alprostadil:Observation of Curative Effectiveness[J];China Pharmacy;2006-09
【Co-citations】
Chinese Journal Full-text Database 8 Hits
1 LI Kang,YANG Jing.Wuhan University School of Basic Medical Sciences,Wuhan 430071,China;Clinical Effects of Lipo-prostagland in E1 with Algobaz Therapy in Patients with Sudden Deafness and Tinnitus[J];Journal of Clinical Rational Drug Use;2012-09
2 ZHENG Jizhao,WANG Caihua;CLINICAL OBSERVATION OF LIPO-PROSTAGLANDIN E_1 IN THE TREATMENT OF SUDDEN DEAFNESS[J];Modern Hospital;2006-12
3 GUAN Shi-xia(Regenex Laboratories Ltd. Co. in Guangzhou,Guangzhou 510730,China)YANG Min,WANG Dong-kai(Shenyang Pharmaceutical University,Shenyang 110016,China);Optimization of Technical Conditions of Alprostadil Liposome[J];China Pharmacy;2008-10
4 LI Lin(Renji Hospital Affiliated to Medical College,Shanghai Jiaotong University,Shanghai 200001, China)LIU Chen(College of Pharmacy,Fudan University,Shanghai 200032,China);Content Determinaton of Main Component in Low Concentration of Alprostadil for Injection by HPLC[J];China Pharmacy;2009-25
5 TAN Zhen(Jiangsu Provincial Governmental Hospital,Nanjing 210024,China);Efficacy Observation of Adjunctive Therapy of Alprostadil Injection for Diabetes in the Elderly[J];China Pharmacy;2010-36
6 WANG Min(Chengdu Dayi Shaoxiang Hospital,Sichuan Chengdu 611330,China);Comparison of the Therapeutic Effect of Alprostadil Injection and Buflomedil Injection in Sudden Deafness[J];Journal of Modern Clinical Medicine;2012-06
7 XUE Rui,CAO Jun-hua,ZHANG Ji,HE Biao(The Affiliated Xiangyang Hospital,Tongji Medical College of Huazhong University of Science&Technology,Hubei Xiangyang 441021,China);Clinical Observation of Calcium Dobesilate in the Treatment of Sudden Deafness[J];China Pharmacy;2013-08
8 SHA Qian-ping;TANG Yong-liang;ZOU Fan;KE Chang-yi;Dept.of Pharmacy,Chongqing Third People's Hospital;Dept.of Hyperbaric Oxygen,Chongqing Third People's Hospital;Dept.of E.N.T.,Chongqing Third People's Hospital;;Clinical Observation of Alprostadil and Yinxing Damo Combined with Hyperbaric Oxygen in the Treatment of Sudden Hearing Loss[J];China Pharmacy;2014-32
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 ZHAO Yuan-xin,LIU Zhen,SHI Si-si,et al;Clinical effects of alprostadil and traditional method treating sudden deafness[J];Journal of Preclinical Medicine College of Shandong Medical University;2004-03
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