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Efficacy and safety of Reduning injection in children with herpangina

XU Xiao-yan~1,HU Yan~1,XUE Jie~1,XU Wei-qin~1,XU Xiao-lin~(2a),DAI Ti-jun~(2b*) (1.Department of Pediatrics,Shuyang Xiehe Hospital,Shuyang 223600,China; 2a.Department of Public Health,2b.Department of Anesthesiology,Xuzhou Medical College,Xuzhou 221002,China)  
Objective To evaluate the efficacy and safety of Reduning injection in children with herpangina.Methods Totally 120 children with herpangina were randomly divided into treatment group(n=60) and control group(n=60).Based on the routine therapy,patients in the treatment group were administered Reduning injection intravenously(0.6~0.8 mL/kg) once daily and those in the control group were administered ribavirin injection intravenously(10 mg/kg)once daily,for 3-5 days.The time for pyretolysis and extinction of herpes,as well as the adverse reactions in two groups were observed. Results The time for pyretolysis and extinction of herpes in the treatment group were significantly shorter than those in the control group(P0.01).The total effective rate and excellent effective rate of the treatment group were significantly higher than those of the control group(P0.05).No adverse reactions were observed in both groups.Conclusion Reduning injection is more effective than ribavirin injection in the treatment of herangina in children.
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