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《World Clinical Drugs》 2011-12
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Effect of triptolide on neonatal rat cardiac myocytes beating rates

LI Hua~(1,2),QIU Yun-liang~2,LI Min,TANG Na-ping~2,MA Jing~2,CHEN Chang-xun~1 (1.School of Chinese Herb,Shanghai University of Traditional Chinese medicine,Shanghai 201203; 2.National Shanghai Center For New Drug Safety Evaluation & Research,Shanghai 201203,China)  
Objective To investigate the effect of triptolide on beating rate of neonatal rat cardiac myocytes.Methods Beating rates of primary cultured neonatal rat cardiac myocytes were monitored by real time cell analyzer(RTCA) for continual 20 hours after giving triptolide at vavious doses(0,2.5,5,10,20,40,80,160 and 200μmol/L).Results Decreased beating rates were observed at 10 min after administration of triptolide(≥2.5μmol/L) and these decreased rates were recovered after 1 h.Beating rates and rhythm of cardiac myocytes did not showed any abnormal from 1 h to 10 h after dosing.Significant decreased beating rates of cardiac myocytes were observed at 20 h after dosing of 160 and 200μmol/L triptolide while normal rhythmic beating was no longer observed.Conclusion Triptolide at higher concentration has the toxic effect on primary cultured neonatal rat cardiac myocytes during the later phase of treatment.
【Fund】: “十一五”重大新药创制科技重大专项资助项目(编号:2008ZX09305-006);; 上海市科学技术委员会新药非临床安全性评价新技术研究(编号:09DZ2290900)。
【CateGory Index】: R285.5
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