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《Journal of International Reproductive Health/Family Planning》 2009-01
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Physiological Variation of Androgen Levels (T and DHT) in Target Tissues at Different Developmental Stages of Male

CUI Yugui1, FU Guangbo2, ZHANG Guiyuan3, QIAN Lixin4, DI Fusong5. 1 Center of Clinical Reproductive Medicine, 4 Department of Urology, and 5 Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China; 2 Department of Urology, The Affiliated Huaian First People's Hospital of Nanjing Medical University, Huaian 214002, China; 3 National Research Institute for Family Planning, Beijing 100081, China Corresponding author: CUI Yugui, E-mail: cuiygnj@njmu.ed.com  
Objective: To study the physiological variation of testosterone (T) and dihydrotestosterone (DHT) levels in androgen target tissues at different developmental stages of male among Chinese Han people, and investigate the effects of androgen in male sex development and sexual maturation. Methods: The foreskins were acquired from 78 subjects (aged from 9 months to 37 years old) who suffered phimosiectomy due to phimosis or redundant prepuce. Foreskins tissues were homogenized and the T and DHT levels of supernatant were measured by RIA. The concentration unit was transformed into pmol/mg per ml protein, and the polynomial curve fitting was adopted to analyze the variation tendency of androgen levels. 8 cases aged from 4 to 6 years old were selected as the children group, 8 cases aged from 14 to 16 years old as the pubertal group, and 6 cases aged from 24 to 26 years old as the adult group. The results were compared among these three groups. Results: Based on the physiological curves of androgen and comparison among the three groups at different developmental stages, our results showed that the levels of T and DHT in target tissues remained low in childhood [(0.368±0.229) nmol/ (mg·L) and (0.589±0.375) nmol/(mg·L)], and the ratio of T/DHT was 0.752±0.405. At the pubertal stage, the volumes of T and DHT raised and reached to the peaks during 14 to 16 years old [(1.120±0.278) nmol/(mg·L) and (2.394±0.813) nmol/ (mg·L)], with T/DHT 0.376±0.161. And at the adult stage, the concentrations of T and DHT remained at relative higher levels [(1.184±0.295) nmol/(mg·L) and (2.250±0.666) nmol/(mg·L)] with T/DHT 0.511±0.164. Conclusions: Our results describe the physiological curves of androgen in target tissues at different developmental stages of male, and confirm the key roles of androgen (T and DHT) in sex development and sexual maturation.
【Key Words】: Pubertal development Sexual maturation of male Androgen Testosterone Dihydrotestosterone
【CateGory Index】: R33
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