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《International Journal of Internal Medicine》 2008-12
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Clinical research on primary spinal epidural lymphomas

RONG Li-min1,LIN Dong-jun2,DONG Jian-wen1,FENG Feng1,XIE Pei-gen1,CAI Dao-zhang1.The Third Affiliated Hospital,Sun Yat-sen University(1 Department of Orthopaedics,2 Department of Hematology) Guangzhou 510630,China  
Objective To analyze the clinical manifestation and management of patients with primary spinal epidural lymphomas.Methods Eleven cases of patients who were pathologically confirmed primary spinal epidural lymphomas were retrospectively analyzed.Results All the 11 patients(8 men,3 women,aged 43~69,mean age 49 years) got the symptom and objective sign of the spinal cord compression.The course of disease ranged from 4 weeks to 1 year(average 4 months).The results of bone marrow biopsy and X-ray were all negative.Signal change was found in magnetic resonance imaging(MRI),and intraspinal parenchyma shadow was found in 9 cases.Three cases were pathologically confirmed of lymphomas by puncturation biopsy.Eight cases which were negative for puncturation biopsy were confirmed lymphomas through operation.All the patients were treated with chemotherapy after pathologically confirmed by puncturation or operation.The follow up time was from 6 months to 10 years.One case was dead 6 months after therapy.The longest duration was 10 years.Conclusion Primary spinal epidural lymphomas was easily to be misdiagnosed in early stage,and the patients who have positive iconography and negative puncturation biopsy results should be paid more attention to.Most patients were sensitive to chemotherapy and the prognosis was relatively good.
【CateGory Index】: R738.1
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