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《International Journal of Anesthesiology and Resuscitation》 2006-06
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Cromolyn sodium protect lung injury caused by intestinal ischemia reperfusion in rats

HEI Zi-qing~(1,*),GAN Xiao-liang~1,LI Shang-rong~1,et al Department of Anesthesiology,3 rd Affiliated Hospital,SUN Yat-sen University,Guangzhou 510630,China  
Objective To investigate the effects of Cromolyn Sodium on the lung injury caused by intestinal ischemia reperfusion in rats.Methods 32 SD rats were randomly divided into four groups: sham group(group A),model group(group B),high dosage group,(treated with Cromolyn Sodium 50 mg/kg,group C);low dosage group(treated with Cromolyn Sodium 25 mg/·kg/,group D).Intestinal damage was induced by clamping the superior mesenteric artery for 45 min and reperfusion for 60 min.Cromolyn Sodium was administrated via intaperitoneal at 15 min before reperfusion.At the end of study,the lungs were immediately removed for determination of lung water content [(wet weight-dry weight) / wet weight x 100%],lung MDA contents and SOD activity,lung permeability index(BALE protein concentration / serum protein concentration) and microscopic examination.Results ① The score of lung injury in group B was higher than the other groups(P0.01),high dosage Cromolyn Sodium provided better protective effects than low dosage(P0.05).② Mast cell number and histamine concentration in pulmonary were no significant difference among four groups.③ Lung water content,lung permeability index increased significantly in group B compared group A(P0.05),Cromolyn Sodium significantly prevented the above changes(P0.05).④ MDA content was significant increased,and SOD activity was significant decreased in group B(P0.01).Cromolyn Sodium attenuated the increase in MDA content and the decrease in SOD activity(P0.05).There was positive correlation between the lung injury score and MDA content,and there was negative correlation between the lung injury score and the SOD activity in the four groups(P0.01).Conclusion Cromolyn Sodium can protect lung injury caused by intestinal ischemia reperfusion by nonspecific antioxidant properties,mast cells in pulmonary have little effect on the lung injury caused by intestinal ischemia reperfusion.
【CateGory Index】: R574
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 LU Yun-Bi, JIANG Bo, ZHOU Han-Liang (Department of Pharmacology, School of Medical Science, Zhejiang University, Hangzhou 310031, China);Effects of salbutamol and sodium cromoglicate on phospholipase D activity during the degranulation of rat peritoneal mast cell[J];Chinese Journal of Pharmacology and Toxicology;2001-05
【Co-citations】
Chinese Journal Full-text Database 8 Hits
1 LUO Gang-jian,GAN Xiao-liang,SHEN Ning,HEI Zi-qing,LI Shang-rong,CHEN Li-xin Department of Anesthesiology,Third Affiliated Hospital,SUN Yat-sen University,Guangzhou 510630,China;Cromolyn sodium ameliorates rat left cardiac function during intestinal ischemia-reperfusion[J];Journal of Southern Medical University;2007-05
2 SHEN Ning,GAN Xiao-liang,PANG Hu-yu,HE Zi-qing Department of Anesthesiology,Third Affiliated Hospital of Sun Yat-sen Uviversity,Guangzhou 510630,China;Role of sodium cromoglycate in brain protection and its effects on tumor necrosis factor-α and interleukin-1β after global cerebral ischemia-reperfusion injury in gerbils[J];Journal of Southern Medical University;2009-03
3 LI Jie-min;SUN Jian;LI Chang-bao;LI Li;YOU Xiang-rong;LI Zhi-chun;LIU Guo-ming;SHENG Jin-feng;Institute of Agro-food Science &Technology,Guangxi Academy of Agricultural Sciences;Guangxi Crops Genetic Improvement and Biotechnology;;Effects of PLD inhibitors on storage properties of postharvest longan fruits[J];Journal of Southern Agriculture;2013-09
4 LI Li1,2,YOU Xiang-rong1,2,SUN Jian1,2*,PENG Hong-xiang3,LI Chang-bao1,HE Quan-guang1,ZHANG E-zhen1,LIAO Fen1,LI Zhi-chun1(1.Institute of Agro-food Science & Technology,Gua ngxi Aca demy of Agricultura l Sciences,Na nning 530007,China;2.Guangxi Crop Genetic Improvement Laboratory,Nanning 530007,China;3.Horticultura l Resea rch Institute,Gua ngxi Aca demy of Agricultura l Sciences,Na nning 530007,China);Relationship between Gene Differential Expression of Phospholipase D and Senescence of Plants[J];Journal of Tropical and Subtropical Botany;2012-01
5 ZHANG Jia1,2,LI Peng2,LI Yi-kui2,LI Lian-da2(1.School of Basic Medical Science,Beijing University of Chinese Medicine,Beijing 100029,China;2.Experimental Research Center of Xiyuan HosPital,China Academy of Traditional Chinese Medicines,Beijing 100091,China);Effect on Tween 80 on the degranulation of RBL-2H3 cells[J];Current Immunology;2009-03
6 GAN Xiao-liang,HEI Zi-qing,LUO Gang-jian,LI Shang-rong,CHEN Li-xin,CAI Jun(Department of Anesthesiology,The Third Affiliated Hospital,Sun Yat-sen University,Guangzhou 510630,China.);Effects of mast cell membrane stabilizer on histamine concentration,MDA content and SOD activity in small intestine after ischemia-reper-fusion injury in rats[J];Chinese Journal of Pathophysiology;2008-01
7 JIANG Bo,LU Yun-bi,Zhou Han-liang,et al (Zhejiang Respiratory Drugs Research Laboratory of State Drugs Administration of China,College of Medical Sciences,Zhejiang University,Hangzhou 310031,China);Role of phospholipase D in priming of rat peripheral leukocytes by lipopolysaccharide and antigen[J];Journal of Zhejiang University(Medicine Sciences);2003-04
8 WANG Ming-xia,ZHANG Jun-zhen,HOU Juan,LIU Ming-feng,LI Lu,LI Dong(The Forth Hospital of Hebei Medical University, Shijiazhuang 050011, China) HAO Li-ya(Xingtai Municipal Third Hospital, Hebei Xingtai 054000, China);Analysis of 482 Cases of Adverse Drug Reaction Reports in Our Hospital[J];China Pharmacy;2012-46
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 Hu keming (Shengsi Peop1e's Hospital, Shengsi 202450);Clinical Analysis of 100 Patients with Disease due to Wind-Warm and Lung-Heat[J];Journal of Zhejiang College of Tcm;1995-03
2 Han Guodong et al. (Tianjin College of TCM, Tianjin);Observation on the Restoration-Promoting Effect of Major Chengqi Decoction on Experimental Pulmonary Damage[J];China Journal of Traditional Chinese Medicine and Pharmacy;1994-05
3 Ren Xiuling1 Zhao Qingshu1 Cheng Zhenfang1 Hao Fuming1 Yan Xiaohong2 Wang Wenli2 Shi Zhiqiang1 Wang Qi1 Yang Hongxin2 Yang Qiaofang1 Li Lin1 Yun Gang1 Zhao Min1(1Department of TCM,Inner Mongolia Medical College,Huhehaote 010020;2Department of Basic Medical College,Inner Mongolia Medical College,Huhehaote 010050);Experimental Study on Expression of Fas and Fas-L of Lung,Skin and Intestine in Deficiency of Lung Qi Model Mice[J];China Journal of Traditional Chinese Medicine and Pharmacy;2007-07
4 ZHANG Wen Jun,XU Guo Ming,LI Zhao Shen,GONG Yan Fang,TU Zhen Xing,XU Ai Fang (Department of Gastroenterology,Changhai Hospital,Second Military Medical University,Shanghai 200433,China);Relationship between serum interleukin-1β and ulcerative colitis[J];Academic Journal of Second Military Medical University;2002-12
5 ZHANG Qing, MAO Bao ling, QIAN Gui sheng, LI Qi, CHEN Zheng tang, XU Jian cheng (Institute of Respiratory Diseases, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China);Changes of TNF-α, IL-1β, and IL-6 levels in plasma and bronchoalveolar lavage fluid of rats after seguential injury with oleic acid and lipopolysaccharide[J];Acta Academiae Medicinae Militaris Tertiae;2004-15
6 YIN Xiao-lin, JIN Li-juan (Department of Pathophysiology, First Military Medical University, Guangzhou 510515, China);Apoptosis of alveolar typeⅡepithelial cells in lung injury after intestinal ischemia-reperfusion[J];Journal of First Military Medical University;2000-04
7 WANG Qun-ying, CHEN Cun-long, WANG Ji-de, LAI Zhuo-sheng, MA Qiang, ZHANG Ya-li Institute for Digestive Diseases of PLA, Nanfang Hospital, First Military Medical University, Guangzhou 50515, China;Expression of pro-inflammation cytokines and activation of nuclear factor κb in the intestinal mucosa of mice with ulcerative colitis[J];Journal of First Military Medical University;2003-11
8 Qian Guisheng. Xinqiao Hospital, The Third Military Medical University, Chongqing 400037;SYSTEMIC INFLAMMATORY RESPONSE SYNDROME,ACUTE LUNG INJURY AND ACUTE RESPIRATORY DISTRESS SYNDROME[J];MEDICAL JOURNAL OF CHINESE PEOPLE'S LIBERATION ARMY;1999-05
9 ZHOU yujie,SU qian The People′s Hospital of Gulou Hospital Group 223800,China;Study the role of inflammation of tetrandrine on airway of chronic obstructive pulmonary disease in rats[J];Journal of Clinical Pulmonary Medicine;2007-08
10 LU Gen fa 1, ZHANG Wen hui 2 (1.Institute of Burn Research, Southwestern Hospital, Third Military Medical University, Chongqing 400038,China; 2.Department of Outpatient, PLA 534 Hospital, Luoyang 471000, China);Metabolism of prostaglandin E2 inhibits T-cell activation[J];Immunological Journal;2002-S1
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 LI Ping, LU YunBi, ZHOU HanLiang, CHEN JiQiang (Dept of Pharmacology, Medical School, Zhejiang University, Hangzhou 310031);Changes of phospholipase D activity of exudate leukocytes in rat carrageenan-induced pleurisy[J];CHINESE PHARMACOLOGICAL BULLETIN;2000-01
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