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《Journal of International Neurology and Neurosurgery》 2010-06
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Related factors for the occurrence of apathy in patients with Parkinson's disease

YANG Jun,WANG Wen-Min,AI Qing-Long.Intensive Care Unit,Xiangfan First People's Hospital,Xiangfan,Hubei 441000,China  
Objective To study the incidence of apathy in patients with Parkinson's disease(PD),and explore the related factors for the occurrence of apathy.Methods Sixty patients with PD were investigated in the Department of Neurology of the First Affiliated Hospital of Kunming Medical College from August 2006 to March 2008.Neurological function,disease severity,and demographic information were assessed by Unified Parkinson's Disease Rating Scale(UPDRS) and self-designed questionnaire.Emotional state and cognitive function were assessed by Modified Apathy Evaluation Scale(MAES),Self-rating Depression Scale,17-item Hamilton Depression Rating Scale(HAMD),and Mini-Mental State Examination(MMSE).Multiple factor regression analysis was carried out to determine the factors for the occurrence of apathy.Results Apathy occurred in 35 out of 60 patients(58.3%),including 14 cases of apathy alone(23.3%) and 21 cases of apathy along with depression(35.0%).Multiple factor regression analysis indicated that the factors for the occurrence of apathy were the use of dopaminergic medicines,and movement and cognitive impairments.Conclusions Apathy is a common clinical manifestation,and it could be a "core" symptom in PD patients.The occurrence of apathy is closely related with movement and cognitive functions.
【CateGory Index】: R742.5
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