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《International Journal of Laboratory Medicine》 2009-10
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Inhibitory effects of baicalin,baicalein and baicalin salt in Radix Scutellariae of Gansu on Candida albi- cans

ZHANG Mei-ling,WANG Hong-wei,TIAN Yuan,et al.Department of Clinical Laboratory, Affiliated Hospital of Gansu College of Traditional Chinese Medicine,Lanzhou 730020,China  
Objective To find out the effective active component on Candida albicans in Radix Scutellariae of Gansu.Methods Radix Scutellariae of Gansu was cleaned,toasted and crushed into power.Baicalin and baicalein were extracted and made into power.Baicalin salt was made from chemical reaction of baicalin and sodium hydroxide.There isolates of Candida albicans from deep fungal infection focus were inoculated in 90 mm Sabouraud plate.On germ free condition,the drilling instrument of 6 mm diameter was used to drill in the Sabouraud plate,and then baicalin,baicalein or baicalin salt power filled the corresponding wells(each well 43.4 mg).Two or three drops of distilled water were added into each well.Bacterial culture was conducted under 35℃,for 24 to 48 hours.Then the bacteriostatic rings were observed.Results The diameter of the bacteriostatic rings was as follows:baicalein[(18.7±2.9)mn];baicalin salt[(12.8±1.5)mm];baicalin(0).Conclusion Baicalein is proved to be the effective active component in Radix Scutellaria of Gansu on Candida albicans,baicalin salt is also effective, but baicalin has no inhibitory effect of Candida albicans.
【Fund】: 甘肃省科技攻关计划项目(2GS064-A43-020-28)
【CateGory Index】: R285
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