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《International Journal of Laboratory Medicine》 2010-12
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Detection of dendritic cell subsets in peripheral blood of the patients with aplastic anemia

JIANG Peng-jun,ZHU Xue-jun,SUN Xue-mei(Department of Hematology,Jiangsu Province Hospital of Traditional Chinese Medicine,Affiliated with Nanjing University of Chinese Medicine,Nanjing 210029,China)  
Objective To measure the dendritic cell(DC) subsets of peripheral blood in patients with aplastic anemia(AA),and explore the significance.Methods The DC1/CD11c+ and DC2/CD123+ subsets from 14 AA patients and 14 healthy controls were measured by flow cytometry with three-color immunofluorescent staining.Results In AA patients' peripheral blood,the rates of CD11c+ DC were significantly increased comparing with that of healthy controls(P0.05),but the level of the CD123+ DC was not changed significantly(P0.05).Conclusion The predominance of CD11c+ DC in peripheral blood of AA patients may be ultimately favor to the Th1-dominated immunity,which may play an important role in the pathogenesis of AA.
【CateGory Index】: R446.61
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