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《International Journal of Laboratory Medicine》 2011-15
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Applicable value of three serology detection methods for the diagnosis of syphilis

Li Aimin,Liu Bin,Cai Feng(Clinical Laboratory Centre,Ruici Hospital,Nantong Jiangsu 226010,China)  
Objective To evaluate the clinical value of ELISA,rapid plasma regain test(RPR) and treponema pallidum particle assay(TPPA) in the detection of syphilis.Methods The serums of 175 syphilitic cases and 120 non-syphilis patients were detected by ELISA、RPR and TPPA.Then,the sensitivity,specificity,false positive rate and false negative rate of different methods were compared.Results The sensitivity and specificity were 74.28% and 78.33% for RPR,100.0% and 96.66% for ELISA,100.0% and 100.0% for TPPA.The sensitivity and specificity of ELISA and TPPA were higher than RPR(P0.05).The false negative rate and the false positive rate of RPR were 25.71% and 21.66%,which were higher than ELISA and TPPA.Conclusion RPR was not suitable for syphilis antibody screening.ELISA could be used for syphilis screening,and TPPA was suitable for confirming positive samples,detected by ELISA.
【CateGory Index】: R759.1
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