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《International Journal of Laboratory Medicine》 2013-02
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Prediction of procalcitonin in children with vesicoureteral reflux

Zou Jiangling (Liuyang Traditional Chinese Medicine Hospital,Liuyang,Hunan 410300,China)  
Objective To explore the predictive value of procalcitonin(PCT) in the diagnosis of urinary tract infection in children with vesicoureteral reflux(VUR) and the relationship with the degree of VUR.Methods Children that came from January 2011 to March.2012 and admitted with the first urinary tract infection from out-patient and in-patient were recruited in the study.The results of PCT,CRP,urine bacterial culture,ultrasonography of the urinary system,voiding cystourethrography(VUCG)were collected for analysis.Results Among 146 children included,51 children(34.9%)had VUR.There was no difference in age and sex in children with VUR(P0.05).The levels of PCT and CRP in VUR group were significantly higher than in those of non-VUR group(1.05 vs 0.4 ng/mL,11.2 vs 13.9 mg/L,P0.05).The diagnostic performance of PCT was superior to CRP.High procalcitonin(≥0.5 ng/mL) was associated with the degrees of VUR(odds ratio 5.5,5% confidence interval 2.3-12.9).The relationship was stronger in middle-grade(odds ratio 9.1,95% confidence interval 1.4-61.7) than low-grade(odds ratio 4.6,95% confidence inerval 1.8-11.7).Conclusion Procalcitonin was potentially a useful marker for determining the presence of vesicoureteral reflux and might be independently predicted the severity grade of vesicoureteral reflux to avoid unnecessary voiding cystourethrography.
【CateGory Index】: R726.9
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