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《International Journal of Laboratory Medicine》 2013-19
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The study of PBMC RORγt mRNA expression in patients with chronic hepatitis B,cirrhosis and liver cancer

Liu Jun;Centre Blood Bank of Liaocheng City;  
Objective To study peripheral blood mononuclear cells Th17cell specific transcription factor RORγt mRNA expression in patients with chronic hepatitis B,cirrhosis and liver cancer.Methods PBMC RORγt mRNA expression in patients with chronic hepatitis B,cirrhosis and liver cancer were measured with real time RT-PCR.Results Healthy control group PBMC RORγ t mRNA expression was 0.31±0.13,hepatitis B group was 1.23±0.25,liver cirrhosis group was 1.36±0.21,liver cancer group was 1.42±0.27.Compared with health control group,hepatitis B,liver cirrhosis and liver cancer group PBMC RORγt mRNA expression have significant differences(P0.01).Conclusion PBMC mRNAγt expression increased in patients with chronic hepatitis B,liver cirrhosis and liver cancer,RORγt plays an important role in the pathogenesis of hepatitis B,liver cirrhosis and liver cancer.
【CateGory Index】: R440
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