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《International Journal of Laboratory Medicine》 2014-02
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Determination of aromatic amino acids in serum of patients with post renal transplantation

Xiao Ledong;Zheng Lin;Zhang Jiang;Tang Aiguo;Mo Ximing;Department of Clinical Laboratory,the First People′s Hospital of Shaoyang;Department of Clinical Laboratory,the Second Xiangya Hospital of Central South University;  
Objective To observe serum tryptophan(Tyr),tyrosine(Trp)and phenylalanine(Phe)concentration change in post-renal transplantation patients,and explore the correlation of aromatic amino acid metabolic change with renal function.Methods Kidney transplant patients and healthy people serum Tyr,Trp and Phe content were determined by high performance liquid chromatography-fluorescence spectrometry(HPLC-FD),and automatic biochemical analyzer was used to detected creatinine,urea nitrogen,uric acid,cystatin C andβ2-microglobulin content.The relationship between aromatic amino acid metabolism and renal function were analyzed.Results Compared with the healthy control group,the concentrations of serum Tyr and Trp in post-renal plantation patients had no significant difference[(63.93±13.75)vs(58.13±16.50)μmol/L;(35.27±7.82)vs(37.15±9.37)μmol/L,P 0.05].The concentration of serum Phe significantly increased than the healthy control group[(60.75±13.55)vs(38.19±10.85) μmol/L,P0.01],which CKD3period,patients Phe concentration was significantly higher than CKD1and CKD2period patients(P0.01).The correlation analysis showed that Phe concentrations correlated with cystatin C andβ2-microglobulin concentration. Conclusion Aormatic amino acid(AAA)metabolic change can be observed in post-renal transplantation patients,which is closely related to the state of renal function.
【Fund】: 湖南省科技计划项目(2010SK3205)
【CateGory Index】: R699.2
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