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《International Journal of Laboratory Medicine》 2014-02
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Diagnosis value of serum free light chain kappa/lambda ratio in kidney damage of patients with chronic kidney disease

Mo Qinong;He Jincai;Sun Linli;Feng Yuli;Yu Wenhui;Yuan Min;Li Chunhua;Deparment of Clinical Laboratory,Shenzhen Traditional Chinese Medicine Hospital, Affiliated to Guangzhou University of Chinese Medicine;  
Objective To evaluate the clinical value of serum free light chain kappa/lambda ratio(sFLC)in kidney damage of patients with chronic kidney disease(CKD).Methods According to the results of serum immune fixation electrophoresis(IFE) and serum free light chainκ/λratio,95cases of patients with chronic kidney disease were divided into three groups:kappa light chain predominate positive group(group A)30cases,lambda light chain positive group of 31cases(group B),chronic renal insufficiency in the control group(C group)34cases and 30cases of healthy physical examination were selected as control group(group D).Immunological transmission turbidimetry was used to detect serum cystatin C(Cys C),C-reactive protein(CRP),free blight chain kappa and lambda concentration levels.urine beta 2microglobulin(β2-MG),trace albumin(MA)and 24hurinary total protein(24hPRO)contents,serum creatinine(CREA)and urine N-acetyl-β-D glycosidase enzymes(NAG)activity were detected by enzymatic method.Results The serum CREA,CRP,Cys C and urine MA,β2-MG,24hPRO concentration levels and NAG activity of group A,group B and group C were obviously higher than those of group D.Compared with group D,the difference was statistically significant(P0.01).The serum CRP,Cys C and urine MA,β2-MG,24hPRO concentration levels and NAG activity of group A and group B were obviously higher than those of group C.The difference was statistically significant(P0.01).Conclusion The measurement of serum free light chain kappa/lambda ratio in renal damage degree evaluation for patients with chronic kidney disease(CKD)has important clinical significance.
【CateGory Index】: R692
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