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《Journal of International Obstetrics and Gynecology》 2009-02
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Urocortin Stimulates Human Myometrial Contractility at Term in Vitro

ZHANG Li, SHANG Tao.Shenyang Obstetric and Gynecology Hospital ,Shenyang 110014,China(ZHANG Li);Department of Obstetric and Gynecology, No.2 Affiliated Hospital of China Medical University, Shenyang 110004, China(SHANG Tao)  
Objective:To study the capability of synthetic Urocortin to directly stimulate human myometrium and to modulate the activity of prostagland F2α and oxytocin .Methods:Myometrial strips were obtained from the upper edge of the uterine incision from 32 elective lower-segment cesarean sections performed before the onset of labor.The samples were cut into two small strips longitudinally.In test strips, added urocortin, Urocortin±PGF2α and Urocortin±oxytocin were added.Myometrial contractivity was recorded by RM-6000 recorder.Results:In urocortin group, the average contraction of test group is 0.626±0.273 and that of control group is 0.641±0.279( 0.05).In Urocortin±PGF2α group, the average contraction of test group is 5.304±0.875 and that of control group is 2.905±0.487(0.01).In Urocortin±oxytocin group, the average contraction of test group is 2.745±0.352, and that of control group is 2.400+0.330(0.05).Conclusion:Urocotin increased the myometrial contractility when PGF2α was added.
【CateGory Index】: R714
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【Citations】
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1 GU Qing 1, Vicki Clifton 2, CUI Ying 1, HUI Ning 1, ZHOU Xiao Ning 1, HE Qian 1, HAN Qing Feng 1, SHA Jin Yan 1, Roger Smith 2 (1. Department of Gynecology and Obstetrics, Changhai Hospital, Second Military Medical University, Shanghai;Detection of urocortin in maternal plasma[J];Academic Journal of Second Military Medical University;2000-12
【Co-citations】
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1 ZHOU Xing-huoDepartment of Obstetrics and Gynecology,People's Hospital of Jing-xian county, 242500;Clinical analysis of treatment effect on cervical carcinoma by means of Neo-adjuvant chemotherapy[J];Journal of Anhui Health Vocational & Technical College;2005-01
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10 SONG Xiuli1 YU Lamei2 WANG Zhuangsheng11 Department of Psychology,Binzhou Medical University,Binzhou 256603;2 Department of Physiology,Binzhou Medical University;The therapeutic effects of paroxetine addition cognitive psychological therapy on patients with postpartum depression[J];Journal of Binzhou Medical University;2011-03
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1 ;Analysis of hormone levels with Premature Ovarian Failure and age women[A];[C];2011
2 TENG Yue,YAN Ling,DONG Wenlan,LAI Jianqiang Haidian Maternal and Child Health Hospital,Beijing 100010,China;Effects of pre-pregnancy BMI on blood glucose,blood pressure and weight in pregnancy[A];[C];2010
3 Yin Shu(Changshou district reproductive health center of obstetrics and gynecology 401220);Behalf of the of tibolone and misoprostol United cervical dilatation rod for postmenopausal take clinical observation[A];[C];2013
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