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《Journal of International Obstetrics and Gynecology》 2009-02
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Urocortin Stimulates Human Myometrial Contractility at Term in Vitro

ZHANG Li, SHANG Tao.Shenyang Obstetric and Gynecology Hospital ,Shenyang 110014,China(ZHANG Li);Department of Obstetric and Gynecology, No.2 Affiliated Hospital of China Medical University, Shenyang 110004, China(SHANG Tao)  
Objective:To study the capability of synthetic Urocortin to directly stimulate human myometrium and to modulate the activity of prostagland F2α and oxytocin .Methods:Myometrial strips were obtained from the upper edge of the uterine incision from 32 elective lower-segment cesarean sections performed before the onset of labor.The samples were cut into two small strips longitudinally.In test strips, added urocortin, Urocortin±PGF2α and Urocortin±oxytocin were added.Myometrial contractivity was recorded by RM-6000 recorder.Results:In urocortin group, the average contraction of test group is 0.626±0.273 and that of control group is 0.641±0.279( 0.05).In Urocortin±PGF2α group, the average contraction of test group is 5.304±0.875 and that of control group is 2.905±0.487(0.01).In Urocortin±oxytocin group, the average contraction of test group is 2.745±0.352, and that of control group is 2.400+0.330(0.05).Conclusion:Urocotin increased the myometrial contractility when PGF2α was added.
【CateGory Index】: R714
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